Antimalarial Flashcards
1
Q
Chloroquine
MOA:
MOR:
AE:
A
MOA: Links and inhibits haemoglobin, therefore blocking detoxification
MOR: Mutation of gene, Pfcrt, which encodes a transmembrane protein in the parasite’s food vacuole
AE:
- Retinal degredation
- Skin itching in West Africans
- Hypotension, heart block , cardiac arrest
- Suicide attempts
-Drug of choice for area of the world w/ no chloroquine resistance
2
Q
Mefloquine
-AE
A
-Active against most strains of chloroquine - resistant P. falciparum
AE: Vvid dreams or nightmares
- Drowsiness/ dizziness
- Decreased coordination
- worsen psychiatric disorders
3
Q
Quinine
AE:
A
AE:
- N/V
- tinnitus
- distrubed vision
- bizarre ideation
- nightmares
- wonder drug from rainforest
- do NOT use for restless leg syndrome
- Part of family rubiaceae: coffee, ipecac, quinine from cinchona
4
Q
Primaquine
A
Activity against RBC stages of malaria
Active against P. vivax
W/ clindamycin = 2nd choice treatment for pneumonia in transplant patients
5
Q
Malarone/ Proguanil
-MOA
A
MOA: inhibitor of electron transport, cytochrome B
Approved for prevention and treatment of malaria
$8.60 per pill/ has to be taken everyday
6
Q
Doxycycline
A
Active against all strains of malaria
