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1. Psychiatry > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

What are the two families of dopamine receptors?

A 
D1 = D1 and D5
D2 = D2, D3, D4
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2
Q

What is the role of the D1 family?

A

stimulate cAMP

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3
Q

What is the role of the D2 family?

A

inhibit adenyl cyclase and voltage activated Ca channels
Open K channels
also occur in the pituitary gland

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4
Q

What dopamine family are more abundant?

A

D1

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5
Q

What dopamine family are more pharmacologically important?

A

D2

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6
Q

Name some 1st gen typical antipyshcotics?

A 
Halloperidol
Chlorpromazine
Thioridazine
Fluphenazine
Zulopentixol
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7
Q

Name some 2nd gen atypical antipyschotics?

A 
Olanzapine
Respiradone
Quetiapine
Clozapine 
Aripriprazole 
Amisulpride
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8
Q

What are the properties of Chlorpromazine? What is it good for?

A

high sedation

good for violent patients

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9
Q

What is the general action of Typical, 1st generation antipsychotics?

A

block D2 receptors in the frontal brain and basal ganglia

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10
Q

What side effects are prominent with 1st generation antipsychotics?

A

Extrapyramidal side effects:
Parkinsonism
Akathisia
Tardive dyskinesia

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11
Q

What is the benefit of atypical, 2nd generation antipsychotics?

A

lower incidence of EPS and negative symptoms

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12
Q

What side effects are common with atypical antipyschotics?

A

metabolic side effects - glucose dysregulation and increased cholesterol

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13
Q

What side effects does Olanzapine have that a patient must be made aware of?

A

may lead to weight gain and metabolic side effects - so use with caution in somebody with T2DM

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14
Q

What is the general mode of action of 2nd generation, atypicals?

A

partial D2 agonists and a 5HT antagonist

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15
Q

When would clozapine be given?

A

when 2 antipyschotics have failed (including one 2nd gen atypical)

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16
Q

What are the important side effects of clozapine?

A 
constipation 
agranulocytosis
neutropenia 
myocarditis
fatigue
17
Q

What do all antipyschotics lower?

A

the seizure threshold

18
Q

What is the general 1st line treatment for schizphrenia?

A

respiradone

olanzapine

1. Psychiatry (23 decks)

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