Antiparasitics

Question 1

Toxoplasmosis Treatment Drugs

Answer 1

Sulfadiazine+ Pyrimethamine

Question 2

Cholorquine

Answer 2

-results in buildup of heme
-toxic for Plasmodium parasite (malaria)
-inhibits phospholipase A
-whorl keratopathy
-bull’s eye maculopathy
-Central and Paracentral Scotoma (most common)

Question 3

Bull’s Eye Maculopathy Risk (Chloroquine)

Answer 3

-dosage >3mg/kg of ideal body weight or 2.3 mg/kg of real body weight
-treatment duration >5 years
-abnormal renal function
-high body fat percentage
-age >60
-liver disease
-concomitant retinal disease

Question 4

Whorl Keratopathy Drugs

Answer 4

CHAI-T
Chloroquine
Hydrochloroquine
Amiodarone
Indomethacin
Tamoxifen

Question 5

Lindane (Kwell)

Answer 5

-prescribed for lice with shampoo (absorbed through exoskeleton) and scabies with lotion
-conjunctivitis if applied to eyelashes