Antibiotics

Question 1

Bacitracin

Answer 1

-inhibition of cell wall synthesis
-prevents transfer of peptidoglycan
-only effective against gram +
-treatment of blepharitis

Question 2

Penicillins

Answer 2

-amoxicillin/dicloxicillin
-inhibits transpeptidase (cell wall synthesis)
-hypersensitivity reactions common
-5 member beta lactam ring

Question 3

Cephalosporins

Answer 3

-cephalexin/ceftriaxone
-all good (+), 3th and 4th good (-)
-similar to penicillin. 1% chance of allergic reaction if allergic to penicillin
-6 member beta lactam ring
-destroys vitamin K (excessive thinning of blood)

Question 4

Ceftriaxone

Answer 4

-3rd gen cephalosporin
-IV gonococcal conjunctivitis and orbital cellulitis

Question 5

Aminoglycosides

Answer 5

-tobramycin/gentamycin
-30S subunit protein synthesis inhibitor
-(buy AT 30)
-available as fortified
-SPK and delayed corneal re-epithelialization

Question 6

Tetracyclines

Answer 6

-tetracycline/doxycycline/minocycline
-30S subunit protein synthesis inhibitor -(buy AT 30)
-do not take with dairy, iron, or antacids (except doxy)
-contraindicated in renal failure (except doxy)
-contraindicated in children and pregnancy (pseudo tumor cerebri)
-mino: blue sclera/conj pigment cysts

Question 7

Pseudotumor Cerebri Contraindicated Drugs

Answer 7

CATS
-Contraceptives
-Aminoglycosides
-Tetracyclines
-Synthyroid

Question 8

Macrolides

Answer 8

-erythromycin/azithromycin/ clarithromycin
-50S subunit protein synthesis inhibitor
-(CEL at 50)

Question 9

Chloramphenicol

Answer 9

-50S subunit protein synthesis inhibitor
-(CEL at 50)
-Fatal aplastic anemia and optic neuritis

Question 10

Lincomycin/Clindamycin

Answer 10

-REVERSIBLY bind to 50S subunit
-(CEL at 50)
-prescribed for MRSA

Question 11

MRSA Treatments

Answer 11

Bacteria Can’t Decide
-Bactrim
-Clindamycin
-Doxycycline

Question 12

Drugs Safe and Unsafe for Pregnancy

Answer 12

She isn’t FAT she is PACing
-Unsafe (FAT): floroquinolones, aminoglycosides, tetracycline
-Safe (PAC): penicillins, azithromycin, cephalosporins

Question 13

Sulfonamides

Answer 13

-sulfisoxazole/sulfacetamide/ sulfamethoxazole/sulfadiazine
-Inhibit Folate acid Synthesis (DNA)
-inhibit dihydroptetroate synthase
-may induce myopic shift
-may cause Stevens-Johnson Syndrome

Question 14

Toxoplasmosis Drug Treatment

Answer 14

sulfadiazine+pyrimethamine

Question 15

Trimethoprim/Pyrimethaminne

Answer 15

-Inhibit Folate acid Synthesis (DNA)
-inhibit dihydrofolate reductase
-bone marrow suppression
Trimethoprim=TMP= Treats Marrow Poorly

Question 16

Fluoroquinolones

Answer 16

-2: ciprofloxacin/oflicaxin
-3: levofloxacin
-4: gatifloxaxin/moxifloxacin/ besifloxacin
-DNA Gyrase and Topoisomerase IV blockers
-All (-) but 3 and 4 also (+)
-tendinitis: LONES hurt BONES
-damage to cartilage and bone growth in children
-all but levo approved in patients 1 year and older

Question 17

BacteriSTATIC Drugs

Answer 17

Tetracyclines
Trimethoprim
Sodium Sulfacetamide
Erythromycin