Antimicrobials Flashcards
Beta lactam antibiotics
Penicillin
Cephalosporins
The most selective antibiotics with high therapeutic index
Cell wall inhibitors
This cell wall inhibitor inhibits synthesis of peptidoglycan precursors and transport of precursors
Bacitracin
Penicillinase resistant penicillin drugs
Methicillin
Nafcillin
Oxacillin
Most potent inhibitor
Glacolamic
Blocks the initial step in protein synthesis
Linezolid
Drugs which bind to the 50s ribosomal unit
Chlorampenicol
Erythromycin
Lincomycin
Lindamycin
Drugs which bind to 30s ribosomal unit
Tetracyclines
Spectinomycin
Minoglycosides
Nucleic acid inhibitor which inhibits RNA polymerase
Rifampicin
Anti-TB drug
Rifampicin
Inhibits nucleic acid
Quinolones
Disrupts DNA
Metronidazole
This cell membrane inhibitor is applied to skin/ topical antibiotic
Polymyxin B
Inhibits folic acid metabolism
SMZ( sulfamethoxazole)
Blocks tetrahydrofolate synthesis
Trimethoprim (TMP)
Interferes with synthesis of folic acid
Dapsone
Inhibits the synthesis of cord factor
Isoniazid
Natural consequence of drug exposure
Antibiotic resistance
Enzymes that chemically inactivate beta lactam
Beta lactamases
Enzymes found on plasmids
Class A enzymes
Beta lactamases that can inactivate extended-spectrum cephalosporins, penicillin and aztreonam
ESBLs (extended spectrum beta lactamases)
Active against ESBL producing strains
Carbapenems
Beta lactamase inhibitor which inhibits esbl activity
Clavulinic acid