Antimicrobial use Flashcards
Most common AB used on farm
- penicillin
- amoxicillin
- tetracyclines
- TMPS
- aminoglycosides
Bactericidal vs bacteriostatic
- bactericidal kills the bacteria
- bacteriostatic suppresses the growth
Penicillin: bactericidal or bacteriostatic?
- bactericidal
Penicillin: safe in pregnancy?
- yes
Penicillin: what does it penetrate in high doses?
- joints
- pleural cavity
- peritoneal cavity
- CNS
What causes the resistance of penicillin?
- beta-lactamase
How is penicillin eliminated?
- kidneys
Examples of aminopenicillins
- cloaxillin
- ampicillin
- amoxicillin
- clavulanic acid
Benefit of aminopenicillins over penicillin?
- work better against gram-negatives
Cephalosporins: bactericidal or bacteriostatic?
- bactericidal
What do cephalosporins work best against?
- gram positive aerobes
Do cephalosporins penetrate the placenta?
- yes
Why are cephalosporins not suitable for intra-mammary administration?
- low lipid solubility so will become trapped
Are cephalosporins safe in the pregnant animal?
- yes
How are cephalosporins eliminated?
- kidney
Examples of 1st gen cephalosporins
- cefalexin
- cefalonium
- cefazolin
Examples of 2nd gen cephalosporins
- not used
Examples of 3rd gen cephalosporins
- ceftiofur
- cefapirin
- cefoperazone
- cefovecin
Example of 4th gen cephalosporin
- cefquinome
What generation of cephalosporins is the most broad spec?
- 4th gen
Potentiated sulphonamides: bactericidal or bacteriostatic?
- bactericidal
What do potentiated sulphonamides work well against?
- gram positive aerobes
- gram negative aerobes
- some anaerobes but not clostridia
What are potentiated sulphonamides deactivated by?
- organic matter e.g. pus
Tissue penetration of potentiated sulphonamides
Good:
- CNS
- lung
- prostate
- skin
- mammary gland
- GIT
- urinary tract
- synovial fluid
- eye
Are potentiated sulphonamides safe in pregnant animals?
- yes
What is potentiated sulphonamides metabolised by?
- liver