Antihistamines Flashcards
1
Q
MOA
A
histamine H1 receptor antagonist
2
Q
used for
A
rhinitis (especailly hay fever) urticaria anaphylaxis angiooedema asthma
3
Q
random things they are also used for
A
nausea and vertigo
cough suppressant
terminal care for their sedating and antiemetic effects
4
Q
difference between 1st and 2nd gen antihistamines
A
1st gen = sedating (cross blood brain barrier)
2nd gen = non sedating
5
Q
6 first gens
A
alimemazine chlorphenamine clemastine cyproheptadine hydroxyzine promethazine
6
Q
5 second gens
A
cetirizine loratadine fexofenadine acrivastine mizolastine
7
Q
what side effects can be caused by 1st gens and why?
A
dry mouth, unirary retention, confusion (mACh receptor antagonists)
8
Q
what SEs are also caused by 1st gens (due to the fact that they cross the BBB)
A
sedation
cognitive impairment
motor retardation
agitation/stimulation
9
Q
what complication of both
A
arrhythmias
10
Q
IMPORTANT INTERACTIONS
A
TCAs - both are antimuscaric and sedative
-macrolide abx
