Antigout: Colchicine

Question 1

Moa

Answer 1

Inhibits processes to prevent leukocytes from invading joints

Question 2

Indications

Answer 2

Treatment and prophylaxis of acute gouty arthritis

Question 3

AE/nursing implications

Answer 3

-GI distress
-HEME: bone marrow suppression, rash, fever, monitor CBC
-hepatoxicity
-peripheral neuropathy

Question 4

Pt teaching

Answer 4

-acute flare ups**
-no grapefruit juice or alcohol
-low purine diet (sardine, spinach, peas, asparagus, anchovies)
-drug interactions
-plenty of fluids

Question 5

Other name (Allopurinol)

Answer 5

-moa: inhibits Uric acid production (decreases sx of gout)
-AE/implications: (CNS: drowsy, HA, vertigo) (renal insufficiency)
-teaching: 2000mL urine output/day, report decreased urine or cloudy, increase fluids