Anti Fungal

Question 1

Amphotericin B deoxycholate

Answer 1

-reserved for only serious infections
-4-12wk therapy (fever, chills, hypotension, leukopenia, thrombocytopenia)
-AE: cardiac arrest, dysrhythmias, resp arrest, tox, hypomagnesemia
-monitor: BUN/Cr (weekly), CBC, LFT, Mg, C&S

Question 2

Nystain (myocastatin)

Answer 2

-indications: oral/intestinal candidiasis
-SE: N/V/D, rash, urticaria
-local irritation
-inspect mucous membranes

Question 3

Azoles

Answer 3

-vaginal/esophageal/systemic candidiasis
-AE: GI upset, hepatoxicity, Stephen Johnson syndrome
-monitor renal function (weekly), AST/ALT (monthly), bilirubin

Question 4

Ecinocandins (terbinafine/Lamisil) (caspofungin/cancidas)

Answer 4

-athlete’s foot, onychomycosis of nails and skin
-long term: at least 12 wk**
-BBW: hepatoxicity
-monitor LFTs