Anti-viral Flashcards
Moa non HIV
Inhibit viral replication
AE
Depends on varying drug
Herpes
-ovir
-goal: decrease duration of lesions, reduce itching, reduce pain
-acyclovir
Acyclovir
-drug of choice of initial and recurrent
-higher doses for acute; lower for viral supress
-AE: HA, N/V/D, phlebitis
-monitor AST/ALT/BUN/Cr
CMV treatment
-ganciclovir: piggyback only, bone marrow tox, contraceptive required during and for 90 days after
-cidofovir
-contraindicated low WBC
RSV treatment
-ribavirin (virazole)
-goal: improve resp status
-BBW: teratogenic effects
-monitor respiratory status closely** DC if deterioration
Influenza
Goal: decrease sx
-amantadine
-rimantadine
-oseltamivir (tamiflu)
-zanamivir (relenza): diarrhea, nausea, sinusitis
Amantadine (symmetrel)
-strain A
-depression, anxiety, inability to concentrate, insomnia
-orthostatic hypotension, peripheral edema
-anorexia, nausea
Rimantadine (flumadine)
-same as amantadine
-fewer CNS adverse effects
-GI upset
Oseltamivir (tamiflu)
-type A and B
-reduces duration
-N/V, abd pain, conjunctivitis, epitaxis
-treatment should begin within 2 days of flu sx onset
Anti-retrovial
-goal: reduce HIV related morbidity/mortality
-slows progression, not cure
-zidovudine (Retrovir): bone marrow supress DC
AE ART
-therapy may be modified
-goal: find regimen that will best control the infection with a tolerable adverse effect profile
-determine success with CD4 count
Hepatitis
-goal: decrease malaise, myalgia, loss of appetite, abd pain, jaundice
-cautious child, teen, renal
-monitor renal and liver
-long contagious period
-AE: pancreatitis
-BBW: lactic acidosis, severe hepatomegaly
Rn implications anti viral
-exactly as prescribed
-start therapy at earliest sign of recurrent episodes
