Anti-tubercular

Question 1

Isoniazid

Answer 1

-drug of choice
-contraindicated: liver dx
-BBW: severe/fatal hepatitis within first 3 mon
-AE: peripheral neurotpathy, hepatoxicity, hyperglycemia

Question 2

Rifampin

Answer 2

-AE: discoloration of body fluids (orange), GI discomfort, hepatoxicity
-accelerates metabolism of warfarin (monitor INR)
-absorption decreases with food (1hr ac or 2hr cs)
-oral contraceptive ineffective

Question 3

Nursing implications

Answer 3

-LFT (elderly and daily alcohol)
-up to 24months
-exactly as ordered
-NO ETOH
-repot: fatigue, N/V, numb, fever, anorexia, depression, jaundice
-monitor therapeutic effects