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Drug interactions > Antiemetics > Flashcards

Antiemetics Flashcards

1
Q

Antihistamine examples

A

Cyclizine
Promethazine

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2
Q

Antihistamine MOA

A

Blocks H1receptors in the vomiting centre in medulla

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3
Q

Antihistamine SE

A

Sedation
Antimuscarinic - dry mouth, blurred vision
Hypotension

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4
Q

Dopamine antagonists MOA

A

Block D2 receptors in chemoreceptor trigger zone

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5
Q

Dopamine antagonists examples

A

Metoclopramide
Domperidone
Droperidol
Levomepromezine
Prochlorperazine
Promethazine

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6
Q

Dopamine antagonists SE

A

Extrapyramidal SE - tardive dyskinesia
Galactorrhoea
Orthostatic hypotension
Sedation
Neuroleptic malignant syndrome
Blood dyscrasias

Droperidol - QTc prolongation + sudden cardiac death

Metoclopramide - prokinetic

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7
Q

Serotonin antagonists

A

Inhibit action of serotonin at 5-HT3 receptor in small bowel, vagus nerve, and chemoreceptor trigger zone

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8
Q

Serotonin antagonists examples

A

Ondansetron

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9
Q

Serotonin antagonists SE

A

QTc prolongation
Constipation
Headache
Flushing

Small R of cleft lip/palate + structural heart defects

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Drug interactions (13 decks)

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