antidepressants - Video lectures Flashcards
A drug that binds to a specific receptor producing an effect identical to that usually produced by the neurotransmitter
Full agonist
Examples of full agnoists
morphine, methadone, oxycodone, hydrocodone, heroin, codeine, fentanyl
A compound that binds to a receptor that blocks or reduces the action of another substance at the receptor site
Antagonist
examples of antagonists
flumazenil (blocks benzodiazepine at GABA)
Schizophrenia drugs block dopamine 2 receptors
slightly sedating
increases appetite
increases both NE and Serotonin
Mirtazapine
Alpha2 antagonist often combined with SSRI or venlafaxine
mirtazapine
Increases NE and DA
does not work on serotonin
bupropion (Wellbutrin)
Can be used in patients with ADHD and depression
bupropion (Wellbutrin)
Cocaine detox
combat SSRI sexual side effects
smoking cessation
bupropion (Wellbutrin)
weak SSRI that does not have sexual side effects and can be used first line for insomnia
Trazodone
Serious side effect of priapism
Trazodone
Highest risk of drug-to-drug interactions
fluoxetine (Prozac)
fluvoxamine (Luvox)
paroxetine (Paxil)
sertraline (Zoloft)
when to switch to a different SSRI
after 4-8 weeks of first failed trial
when to switch to a different drug class
after two SSRIs have failed
consider for patients with anxiety disorders along with depression
Paxil (paroxetine)
Venlafaxine (Effexor)
Duloxetine (cymbalta)