Antidepressants

Question 1

what is the mechanism of linezolid and phenlzine?

Answer 1

they are monoamina oxidase inhibitors leading to less breakdown of serotonin, dopamine and NE

Question 2

name the monoamine oxidase inhibitors

Answer 2

linezolid and phenelzine

Question 3

what are monoamine oxidase inhibitors niche use?

Answer 3

atypical depression with mood reactivity/hypersomnia and hyperphagia

Question 4

what is the main SE with monoamine oxidase inhibitors? linezolid and phenelzine

Answer 4

serotonin syndrome and hypertensive crisis

Question 5

what is the primary use of monoamine oxidase inhibitors?

Answer 5

parkinsons

Question 6

name the tertiary tricyclic antidepressants

Answer 6

amitriptyline, imipramine, doxepin, clomipramine

Question 7

name the secondary tricyclic antidepressants

Answer 7

amoxapine, desipramine, nortriptyline,

Question 8

what is the difference between tertiary and secondary tricyclic antidepressants?

Answer 8

secondary have fewer adverse effects

Question 9

name five things TCAs are used for

Answer 9

migraine prophylaxis
insomnia
neuropathic pain
nocturnal enuresis 
OCD

Question 10

what TCA is used for migraine prophylaxis?

Answer 10

amitriptyline

Question 11

what TCA is used for insomnia?

Answer 11

amitriptyline

Question 12

what TCA is used for neuropathic pain?

Answer 12

amitriptyline

Question 13

what TCA is used for nocturnal enuresis?

Answer 13

imipramine

Question 14

what TCA is used for OCD?

Answer 14

clomipramine

Question 15

name the five types of effects TCAs can have

Answer 15

SSRI
SNRI
antihistamine
anticholinergic
alpha antagonists

Question 16

what is severe SE with TCAs?

Answer 16

cardiac arrhythmias

Question 17

name the six SSRIs

Answer 17

fluoxetine
fluvoxamine
paroxetine
sertraline
escitalopram
citalopram

Question 18

what is mechanism of SSRIs?

Answer 18

block serotonin reuptake

Question 19

what SSRI has the longest half life?

Answer 19

fluoxetine

Question 20

what SSRI has the shortest half life?

Answer 20

fluvaxomine

Question 21

how long does it take SSRIs to show a potential effect?

Answer 21

2-4 weeks

Question 22

what are the main adverse effects with SSRIs

Answer 22

serotonin syndrome
transient GI distress
sexual dysfunction…decreased libido
SIADH

Question 23

name five situations that call for SSRIs

Answer 23

MDD, generalized anxiety disorder, panic disorder, OCD, bulimia, PTSD

Question 24

name the two SNRI drugs

Answer 24

venlafaxine and duloxetine

Question 25

what is MoA of SNRI?

Answer 25

inhibit 5-HT/serotonin and NE reuptake

Question 26

what are three adverse effects of SNRI?

Answer 26

increased BP, stimulant effects, sedation/nausea

Question 27

name the drug with an amphetamine like structure that is used for depression Rx

Answer 27

Buproprion

Question 28

what is buproprion also used for?

Answer 28

smoking cessation and to help increase sex drive from antidepressant use

Question 29

what are the three targets of mirtazapine in its MoA?

Answer 29

histamine, alpha, and 5-HT serotonin antagonist

Question 30

what are the side effects of mirtazapine?

Answer 30

sedation and weight gain

Question 31

what is the MoA of trazodone?

Answer 31

blocks 5-HT serotonin, alpha adrenergic and histamine receptors

Question 32

what is trazodone primarily used for?

Answer 32

insomnia…need very high dose for antidepressant effect

Question 33

what are the main SEs of trazodone?

Answer 33

orthostatic HTN
SEDATION
priapism

Question 34

name the element used for bipolar Rx

Answer 34

lithium

Question 35

what can lithium be used in addition to to treat MDD?

Answer 35

an antidepressant

Question 36

what three drug classes does lithium interact with?

Answer 36

NSAIDS
ACE/ARBs
Diuretics

Question 37

name the main SEs of lithium

Answer 37

tremors
insipidus in kidneys
hypothyroidism
seizure..coma..death