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FRACP 2023 Cram Homicrons Edition > Antibodies = Dx > Flashcards

Antibodies = Dx Flashcards

1
Q

ANA

A

30% baseline population positive

SLE
JIA - assoc risk of uveitis
Dermatomyositis
Scleroderma
Psoriatic arthritis- assoc risk of uveitis
?MCTD

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2
Q

dsDNA

A

SLE- high specificity, assoc lupus nephritis

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3
Q

Anti-Smith

A

Highly specific for SLE; associated with lupus nephritis

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4
Q

Anti-Smooth muscle

A

Autoimmune hepatitis

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5
Q

Anti-Pm-Scl

A

Sclerodermatomyositis
Polymyositis

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6
Q

Anti-Ro (ENA)

A

SLE- associated with neonatal lupus/CHB/thrombocytopenia
Sjögren syndrome

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7
Q

Anti-La (ENA)

A

SLE- associated with neonatal lupus/CHB/thrombocytopenia
Sjögren syndrome

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8
Q

d

A
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9
Q

Anti-Histone

A

Drug induced SLE

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10
Q

Anti-Centromere

A

Limited cutaneous systemic sclerosis

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11
Q

Anti-Scl70 (topoisomerase 1)

A

Systemic sclerosis/scleroderma

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12
Q

cANCA/PR3

A

granulomatosis with polyangiitis (Wegener), cystic fibrosis

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13
Q

pANCA/MPO

A

microscopic polyangiitis
polyarteritis nodosa
SLE
inflammatory bowel disease
cystic fibrosis
primary sclerosing cholangitis
Henoch-Schönlein purpura
Kawasaki disease
Churg-Strauss syndrome

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14
Q

Anti-CCP

A

RF positive JIA- specific, may be positive before RF

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15
Q

ANA anti centromere antibody

A

CREST

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16
Q

HLA B8, HLA DR3

A

Scleroderma/Raynaud’s

17
Q

HLA-B8, DRB1/ DQA1

A

Juvenile Dermatomyositis

18
Q

HLA-DR1 what condition does it protect against anterior uveitis

A

JIA

19
Q

Anti-PF4 complex

A

Heparin induced thrombocytopenia

FRACP 2023 Cram Homicrons Edition (29 decks)

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