antibiotics/antivirals Flashcards

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1
Q

describe antibiotics

A

a chemical able to inhibit the growth of, or to kill, micro-organisms, particularly bacteria

they prevent the bacteria from reproducing or destroying them

each antibiotic is only effective for certain types of bacterial infections and cannot be used to treat viral infections

doctors assess the cause of infection and prescribe as necessary

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2
Q

what do antibiotics do

A
  1. inhibition of DNA synthesis
  2. inhibition of cell wall/synthesis
  3. lysis of the cell membrane
  4. inhibition of protein synthesis
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3
Q

what are bactericidal

A

disrupt synthesis of cell wall/cell membrane

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4
Q

what are most antibiotics based of

A

30% of antibiotics are penicillin based but bacteria have developed resistance

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5
Q

how many people are allergic to penicillin

A

10% of people

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6
Q

where does cephalosporin come from

A

it is derived from fungus which interferes with cell wall synthesis

less allergic reactions in human population

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7
Q

what is bacteriostatic

A

stop bacteria from reproducing by interfering with protein synthesis

disrupt action of bacterial enzymes

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8
Q

what is streptomycin

A

produced by actinomycetes which live in the soil and produce branching filaments

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9
Q

examples of antibiotics that interfere with protein synthesis

A

erthromycin, neomycin, tetracycline and vancomycin

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10
Q

what is broad spectrum

A

affect a wide range of different types of bacteria

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11
Q

what is narrow spectrum

A

are effective only against specific types of bacteria

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12
Q

what does antibiotic resistance refer to

A

bacteria have evolved and developed resistance to certain antibiotics

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13
Q

what is multiple drug resistance

A

bacteria are resistance to multiple types or all available types of antibiotics

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14
Q

what is total drug resistance

A

resistant to all types of antibiotics
i.e some strain of tuberculosis and gonorrhoea

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15
Q

describe antivirals

A

antivirals are a drug used for the treatment of viral infections

antibiotics are ineffective against viruses- no treatment for colds, chicken pox or measles

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16
Q

why are antivirals hard to make

A

difficult to find a drug to combat viruses unique replication method

17
Q

what do current antivirals target

A

HIV, herpes, hepatitis B and C, influenza A and B

18
Q

how do antivirals work

A

antivirals bind to the viral DNA or RNA

inhibit the development of viruses through targeting viral proteins that can be disabled which slows down their replication

19
Q

how can antivirals help

A
  1. prevent viral attachment and/or entry
  2. inactivate extracellular virus particles and prevent them from uncoating
  3. prevent replication of the viral genome
  4. prevent synthesis (transcription/translation) of specific viral protein
  5. prevent assembly or release of new infectious virions/viral particles