Anti-Hypertension Drug Therapy Deck 3

Question 1

Minoxidil more

Answer 1

selecive dialation of arterioles

Question 2

Minoxidil more intense

Answer 2

More intense dilation than hydralazine, but causes more severe adverse reactions

Question 3

Minoxidil used for severe

Answer 3

Used for severe hypertension unresponsive to safer drugs

Question 4

Minoxidil ADR

Answer 4

Reflex tachycardia
Sodium and water retention
Hypertrichosis
Pericardial effusion
Other

Question 5

Sodium Nitroprusside [Nitropress] is the

Answer 5

fastest acting antihypertensive agent

Question 6

Sodium Nitroprusside [Nitropress] causes

Answer 6

venous and arteriolar dialation

Question 7

Sodium Nitroprusside [Nitropress] administration

Answer 7

IV

Question 8

Sodium Nitroprusside [Nitropress] onset

Answer 8

Onset: Immediate (BP returns to pretreatment level in minutes when stopped)

Question 9

Sodium Nitroprusside [Nitropress] used for

Answer 9

Used for hypertensive emergencies

Question 10

Sodium Nitroprusside [Nitropress] adverse

Answer 10

Excessive hypotension
Cyanide poisoning
Thiocyanate toxicity

Question 11

Alpha 1 blocker MOA

Answer 11

Dilate both resistance and capacitance vessels

Question 12

Alpha 1 blocker dialate

Answer 12

Dilate both resistance and capacitance vessels

Question 13

Alpha 1 net effect

Answer 13

Net effect: BP reduce, may cause retention of Na and water when given without a diuretic

Question 14

slective alpha 1 receptor blockers do not

Answer 14

Selective alpha 1 receptor blockers do not cause reflex tachycardia

Question 15

alpha one decrease what and increase what

Answer 15

Decreases TG, increase HDL

Question 16

alpha one blocker not recomended

Answer 16

for initial monotherapy
Consider patients with HTN and BPH
Consider giving with a diuretic

Question 17

Alpha 1 blocker SE

Answer 17

First-dose phenomenon: dizziness or syncope
Hypotension
CNS: depression, lassitude, vivid dreams
Priapism
Administer initially at HS and titrate slowly
Precautions: liver disease, prostate cancer, cataract surgery
Contraindications: sensitivity

Question 18

common combination

Answer 18

Thiazide and ACE/ARB

Question 19

ACCOMPLISH trial

Answer 19

long-acting dihydropyridine calcium channel blocker plus a long-acting angiotensin-converting enzyme (ACE)inhibitor/ARB

Question 20

other combination

Answer 20

BB + thiazide or dihydropyridine CB

Question 21

ACE-I or ARB – likely to be less

Answer 21

ACE-I or ARB – likely to be less

Question 22

Beta blocker use in caution in

Answer 22

Beta blocker use in caution in

Question 23

Consider BP >20/10 mmHg

Answer 23

above goal

Question 24

Follow-up

Answer 24

Start one drug, titrate to maximum, then add a second dose
Follow-up monthly until BP goal is met.
BP at goal, follow-up every 3 to 6 months
Monitor serum potassium, creatinine and urine microalbumin 1 to 2 times per year

Question 25

monotehrapy

Answer 25

thiazide-type diuretic

chlorthaladone prerred

Question 26

monitor what with thiazide type

Answer 26

hypokalemia

Question 27

chlorthalidone and indapamide are

Answer 27

signifcantly more potent antihypersetnive agents that hydrochlorothizide, at simlar dose levels

Question 28

loop diuretics moa

Answer 28

acts on acending loop of henle to block reabsorption

Question 29

loop pharmacokinetics

Answer 29

rapid onset PO 60 min IV 5 min

Question 30

loop use

Answer 30

pulmonary edema, edematous states, hypertension

Question 31

loop ADR

Answer 31

hyponatremia, hypochloremia, dehydration, hyoptnesion, hyopkalemia, ototoxicity, hyperglycemia, hyperuricemia