ANS Anatomy Jensen Lecture Flashcards
Mean arterial pressure determined by
- cardiac output
- systemic vascular resistance
cardiac output composed of
- heart rate
- stroke volume
heart rate also referred to as
- automaticity
stroke volume referred to as
- myocardial contractility
systemic vascular resistance referred to as
- vascular tone
- smooth muscle contractility
two synthetic beta agonists
- dobutamine
- isoprotenerol
two endogenous beta agonists
- NE
- Epi
dobutamine affinity for which beta adrenergic receptor
- B1 > B2
isoproterenol affinity for which beta adrenergic receptor
- B1 and B2
Beta adrenergic receptor activation pathway
- increased cAMP
- increased extracellular Ca2+ entry
- increased intracellular Ca2+ release
- increased contractile force
- increased stroke volume
- increased cardiac output
the most important difference between EPI and NE
- low affinity of NE for beta 2
NE effect on arterial resistance
- increases arterial resistance
- only acts on alpha 1
EPI effect on arterial resistance
- mixed effect on resistance
- acts on alpha 1 and beta 2
HCN channel responsive to
- cAMP activity
- increase influx of Na+
- increases phase 4 depolarization
PKA targets
- DHP channel
- makes threshold more negative
stimulating beta 1 adrenergic receptors pathway
- increases adenylyl cyclase
- increase PKA
- increases Ca2+ and HCN channel
- increases phase 4 slope and decreases threshold
contraction of smooth muscle is caused by
- Ca2+ concentration
if smooth muscle tone is high throughout the body, what will happen to systemic vascular resistance
which leads to what effect on BP
- systemic vascular resistance will rise
- increased blood pressure
baroreflex response to an increase in SVR
- decrease in heart rate
THINK OF IT IN TERMS OF MATH
YOU WANT MAP TO STAY THE SAME AND SVR HAS INCREASED. THEREFORE YOU NEED CO TO DECREASE.
CO IS COMPOSED OF BY HR AND SV. DECREASE HR
effect of blocking acetylcholine binding to M2 receptors
- increases heart rate
