ANS Flashcards
Cholinergic Drugs(Direct Acting)?
• Acetylcholine
• Carbachol
• Bethanechol
• Pilocarpine
What’s the Therapeutic use of Carbachol?
◦ Glaucoma
◦ Post-operative paralytic ileus
◦ Post- operative retention of urine
What’s the Therapeutic use of Neostigmine?
◦ Myasthenia gravis
◦ Reversal of neuromuscular blockade
What’s the Adverse effects of Cholinergic Drugs?
• Increased fluid: lacrimation, salivation, sweating , Urgency and spontaneous
micturition
• Respiratory: Bronchospasm and increased bronchial secretion
• Heart: Bradycardia and hypotension
• GI: Abdominal Colic, vomiting, diarrhea, hyperacidity
Example of IRREVERSIBLE ANTI-CHOLINESTERASES?
Organophosphorous compounds
Which drug to Treatment of toxicity?
Atropine
Muscarinic receptor antagonists?
◦ Benztropine
Ipratropium
◦ Oxybutynin
Tropicamide
◦ Scopolamine(hyoscine)
Pirenzepine
Therapeutic use of Tropicamide?
Fundus examination and iridocyclitis
(Mydriatic)
Therapeutic use of Hyoscine?
Intestinal, biliary and renal Colic
Motion sickness .
Therapeutic use of Oxybutynine?
Nocturnal enuresis and urinary
incontinence
Therapeutic use of Benztropine?
Benztropine
Therapeutic use of ipratropium?
Bronchial asthma
Therapeutic use of Pirenzepine?
Peptic ulcer:
What’s the Adverse effects of Muscarinic receptor antagonists?
▪ Dry mouth
▪ Blurred vision, dry eye, increase in IOP (glaucoma)
▪ Tachycardia
▪ Constipation
▪ Retention of urine
▪ Hot and flushed skin
What’s the Adverse effects of Non-selective Adrenergic Agonist?
➢ Gangrene if injected around fingers & toes
➢ Hypertension , leads to cerebral hemorrhage
➢ Tachycardia, palpitation, angina and
arrhythmia
