kintics Flashcards
is the study of drug movement throughout the body.
pharmacokinetics
movement of a drug from its site of administration into the blood.
Absorption
in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or the systemic circulation.
The first pass effect
drug movement from the blood to the interstitial space of tissues and from there into cells.
Distribution
Drug distribution is determined by three major factors:
blood flow to tissues,
the ability of a drug to exit the vascular system, the ability of a drug to enter cells.
The rate at which drugs are delivered to a particular tissue is determined by?
by blood flow to that tissue.
also known as biotransformation, is defined as the chemical alteration of drug structure.
Drug metabolism
increase rates of drug metabolism are
inducers
decrease rates of drug metabolism
inhibitors
removal of drugs from the body.
EXCRETION
the time required for the amount of drug in the body to decrease by 50%.
Drug half-life