Anaphylactic shock Flashcards
1
Q
What is anaphylactic shock?
A
Type I hyper-sensitivity reaction due to release of histamine
2
Q
What is the pathophysiology of anaphylactic shock?
A
IgE antibody-mediated hypersensitivity reaction → degranulation of mast cells → massive histamine release → systemic vasodilation, increased capillary leakage
3
Q
What causes anaphylactic shock?
A
Drugs (i.e. penicillin, contrast media)
Food allergies
4
Q
What are the clinical features of anaphylactic shock?
A
Tachycardia, tachypnea
Hypotension with a narrow pulse pressure
Flushed, itchy skin
Bronchospasm, laryngeal edema
