Amphetamines Flashcards
What is Ma huang?
A traditional Chinese medicine herb that has been used therapeutically for 5000 years
Who is Lazar Edeleanu?
He synthesized alpha-methylphenethylamine (amphetamine) in 1887 to treat asthma
What does L-amphetamine do?
Raises BP, opens nasal passages, causes headaches
What does D-amphetamine do?
Has the same effects as L-form but also elevates mood and enhances energy
Why does meth have increased potency and brain effects in relation to L-amphetamine and D-amphetamine?
Increased lipid solubility due to the addition of a methyl group
Easier to enter the BBB
What can meth be made from?
Pseudoephedrine or ephedrine from over-the-counter decongestants
Commercial phenylacetone
What is the process to make meth from decongestants?
Nagai synthesis
What are the processes to make meth from commercial phenylacetone?
Reductive amination or Leuckart synthesis
Why are amphetamines able to bind to neurotransmitter transporters?
Because of their chemical similarity to catecholeamines
What comprises the catecholamine nucleus?
A phenolic group with 2 hydroxyl groups
How AMPHs be absorbed?
Ingested, injected, snorted, or smoked
What is ice?
HCl salt which is smokeable meth
What is the half-life of ice?
12 hours
What is the bioavailability of ice?
Effectively absorbed from the GI tract, 70-100% bioavailability
Does meth or cocaine last longer in the blood?
Meth lasts much longer than cocaine
Where are AMPHs distributed?
Brain, lungs, liver, kidney, spleen
What is the onset of AMPHs?
30-120 minutes
Where are AMPHs excreted?
Kidneys, sweat, saliva