Amino acid metabolism - tissue relationships Flashcards
What does the liver do with the amino acids it receives from the diet when its well fed?
- Liver remodels the aa content from 25% BCAA to about 60% BCAA
- It doesn’t use BCAAs for itself, it saves them for muscles
Where do amino acids come from when fasting?
the muscles
What is the amino acid content coming out of the muscles?
- 25% alanine
- 25% glutamine
- 50% other aa
Where does the glutamine from the muscles go during a fast?
It goes to the gut or the kidney
What serves and an expentable source of aa?
skeletal muscle protein
What are glutamine and alanine considered?
Nitrogen carriers
what is the energy source for muscle during fasting states?
BCAA’s
What aa can turn into pyruvate?
alanine
lactate
gycer
What does kidney use glutamine for?
- Buffer
- Nitrogen resource for biosynthesis
when glutamine releases 1 NH3, what does it become?
What about when it releases 2 NH3
glutamate
a-ketoglutarate that gets used in Krebs for energy
Alannine can get transaminated into what?
pyruvate
what is the primary source of fuel for the kidneys in normal and fasting conditions?
glutamine - it uses the carbon structures
What energy source does the renal medulla use?
glucose
What does the renal cortex uses, aa?
lactate, can get lactate from pyruvate
What is the major fuel of the gut?
glutamine
