amino acid derivatives: neurotransmitters

Question 1

what are the three paths of tyrosine?

Answer 1

• neurotransmitters
• thyroid hormones
• melanin

Question 2

simple path, thyosine to neurotransmitter

Answer 2

tyrosine - L Dopa - Dopamine - Norepinephrine - epinephrine

Question 3

Simple, tyrosine to thyroid hormone?

Answer 3

tyrosine - thyroxine

Question 4

simple, tyrosine to melanin

Answer 4

tyrosine - L Dopa - melanins

Question 5

What does tyrosine hydroxylase do?

Answer 5

hydroxylate tyrosine to L-Dopa

Question 6

What does tyrosine hydroxylase require?

Answer 6

tetra hydro biopterin

NADPH

Question 7

what is the Rate limiting step to make catecholamines?

Answer 7

the step turning Tyrosine to L dopa using tyrosine hydroxylase

Question 8

how is dopamine made from L dopa?

Answer 8

aromatic hydrocarbon decarboxylase

Question 9

aromatic hydrocarbon decarboyxlas requires what cofactor?

Answer 9

PLP pyroxidal phosphate…B6

Question 10

what cofactors for dopamine to norepinephrine? 3

Answer 10

Cu++
Vit C
O2

Question 11

Vitamin C is used for what 5 things?

Answer 11

antioxidant
iron absorbtion
catacholemine synth
collagen synthesis
bile salts

Question 12

Cu is used for what 5 things

Answer 12

electron transport
catecholamine synth
tyrosinase
SOD
iron metabolism

Question 13

What amino acid can become tyrosine?

Answer 13

phenylalanine

Question 14

What is the difference in enzyme that turns tyrosine to L-dopa for melanin or catecholamine synth?

Answer 14

Catechlamine synth - BH4

Melanins - Cu++ dependent

Question 15

What is BH4

Answer 15

tetra hydro bio pterin

Question 16

Dopa to dopamine uses what?

Answer 16

B 6 - pyradoxyl phosphate