alzheimers

Question 1

common causes of dementia?

Answer 1

alzheimers
vascular dementia
lewy body dementia

Question 2

common frontotemporal dementia?

Answer 2

picks

Question 3

function of apoprotein E4?

Answer 3

encodes a cholesterol transport protein

Question 4

in alzheimers, you get widespread cerebral atrophy, affecting mainly?

Answer 4

hippocampus and cortex

Question 5

microscopically, the deposition of plaques and neurofibrillary tangles due to?

Answer 5

played are due to A beta amyloid protein and neurofibrillary tangles are abnormal aggregations of tau proteins

Question 6

in AD, tau proteins are excessively?

Answer 6

phosphoylated

Question 7

what are neurofibrillary tangles?

Answer 7

paired helical filaments are partly made from a protein called tau

Question 8

the three acetylcholinesterase inhibitors used in AD?

Answer 8

donepizil, galantamine and rivastagmine

Question 9

moderate Alzheimer’s who are intolerant of, or have a contraindication to, acetylcholinesterase inhibitors. what are they given?

Answer 9

memantidine

Question 10

what drug class is mimentidine?

Answer 10

a NMDA receptor antagonist

Question 11

how do you differentiate lewey body dementia from others?

Answer 11

Symptoms fluctuate
Association with parkinsonism (Lewey bodies found in parkinson as well)
causes visual hallucinations (often unpleasant and persecutory)

Question 12

which drug can help improve symptoms in lewey body dementia?

Answer 12

rivastigmine