alpha adrenoreceptor antagonists

Question 1

name two?

Answer 1

tamulosin, doxazosin

Question 2

indication for use

Answer 2

[1] improvement symptoms in benign prostatic hyperplasia (1st line)
[2] add on treatment in resistant hypertension

Question 3

what can be added to the treatment for indication 1

Answer 3

5 alpha reductase inhibitor

Question 4

mechanism of action?

Answer 4

selective for alpha adreno receptors on smooth muscle of blood vessels and urinary tract (bladder neck and prostate).
stimulation induces contraction, blockade induces relaxation therefore alpha blockers induce vasodilation and reduce bp and resistance to bladder outflow is reduced

Question 5

AE

Answer 5

syncope
postural hypertension
diziness

Question 6

warning/contraindications?

Answer 6

not for those with postural hypertenshion

Question 7

interactions

which drug is an ‘especially’

Answer 7

Additive effect with anti-hypertensives therefore use with caution to ensure hypotension doesn’t occur esp beta blockers

Question 8

key consideration

Answer 8

many men with Benign prostatic hyperplasia also have hypertension so consider use of doxozin earlier in treatment plan so the patient is only on 1 medication for both conditions