alpha 5 reductase inhibitor Flashcards
1
Q
indications
A
1) benign prostatic hyperplasia 2nd line or additive to
2) relieve lower urinary tract symptoms such as dysuria
2
Q
MOA
A
inhibits 5 alpha reductase which converts testosterone into dihydrotesterone
this causes shrinkage of the prostate and increases urinary flow
3
Q
SE
A
gynaemastica prostate shrinkage increased risk of male breast cancer reduced libido hair growth
4
Q
what is the preferred treatment? how long does effects of ths take to be seen?
A
up to 6 months
slow activity therefore alpha blockers preferred or combined therapy
5
Q
warning/contraindications
A
can cause abnormal male genitalia development therefore do not let women who are likely to become pregnant be in contact e.g. partner is on this medication via unprotected sex
6
Q
name an example
A
finasteride
