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Peds Boards > Allergy, Immunology, Derm > Flashcards

Allergy, Immunology, Derm Flashcards

1
Q

Cold Abscesses

A

Hyper IgE Syndrome

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2
Q

Hyper IgE Syndrome Genetic Mutation

A

STAT3

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3
Q

Hyper IgE Syndrome - Features

A

eczema, scoliosis, hyper-extensibility

cold abscesses, retained primary teeth, pneumatoceles

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4
Q

Type 3 Hypersensitivty Reaction

A

Immune-Complex

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5
Q

Type I Hypersensitivity Reaction

A

immediate rxn: anaphylaxis, hives/urticaria, allergic rhinitis/asthma

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6
Q

Type 2 Hypersensitvity Reaction

A

Cytotoxic, IgG or IgM mediated

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7
Q

Examples of Type 2 Hypersensitivity Reactions

A

AIHA, thrombocytopenia, leukopenia
Good Pasture Syndrome
Myasthenia Gravis

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8
Q

Examples of Type 3 Hypersensitivity

A

Serum Sickness, Arthrus Reaction

Autoimmune diseases

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9
Q

Type 4 Hypersensitvity Reactions

A

Delayed-type hypersensitvity

i.e: PPD, some asthma phenotypes

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10
Q

Duncan Syndrome

A

X-linked lymphoproliferative disease

several or fatal reactions with EBV

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11
Q

Leukocyte Adhesion Deficiency - Symptoms

A

delayed umbilical cord separation
omphalitis
severe gingivitis
skin lesions: cigarette paper scarring

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12
Q

LAD Type 1 diagnosis

A

CD18 by flow cytometry

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13
Q

Hyper IgM Syndrome

A

normal/high IgM, low IgA, IgE, IgG
recurrent infections, remember PCP
CD40 ligand

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14
Q

Serum Sickness, timeline for presentation

A

6-12 days after exposure

Type III hypersensitivity

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15
Q

DRESS syndrome, timeline for presentation

A

2-8 weeks after exposure

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16
Q

Antibody found in secretions

A

IgA

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17
Q

When do infants produce their own IgG?

A

2-3 months of age

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18
Q

Transient Hypogammaglobulinemia of Infancy

A

normal/variant production, will usually produce normal IgG levels by 3-4 years
no treatment unless recurrent severe infections (give IVIG)

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19
Q

Non-IgE reactions, common agents

A

NSAIDS, contrast, ASA

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20
Q

Chronic granulomatous disease - Features

A

X-linked
Recurrent abscesses
S aureus, Serratia, Burkholda, Aspergillus

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21
Q

Chronic Granulomatous Disease - Testing/Defect

A

DHR / dihydrorhodamine oxidation

cannot generate the respiratory burst

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22
Q

Atopic Dermatitis =

A

itch that rashes

infants: face, extensor surfaces
kids: flexor surfaces

23
Q

Ataxia-Telangiectasia: inheritance and defect

A

AR

ATM mutation, DNA breaks

24
Q

Ataxia-Telangiectasia features

A

ataxia, ocular teleangiectasis

sinopulmonary disease, bronchiectasis

25
Q

Level elevated in Ataxia-Telangiectasia

A

alpha-1-fetoprotein

26
Q

Ataxia Telangiectasis complication

A

maligiancy: lymphoma, lymphoblastic leukemia

27
Q

Bloom Syndrome

A

similar to ataxia teleangiectasis but WITHOUT ataxia
immunodeficiency
DNA ligase 1 disorder

28
Q

What immunodeficiency associated with prolonged bleeding from circumcision

A

Wiskott-Alrich Syndrome

29
Q

Types of Hereditary Angioedema

A 
low C4 (substrate for C1-INH) 
type 1:  low C1-INH
type 2: normal CI-INH
30
Q

Food Allergy Mmenmoic in Kids

A

WEMPS

Wheat, Egg, Milk and Soy, Peanuts, Seafood

31
Q

SCID

A

eczema, FTT, diarrhea
lymphopenia
absent thymus

32
Q

SCID - blood products

A

give irridiated

non-irridiated contains T lymphocytes which can cause GVHD

33
Q

X-linked (Bruton) Agammaglobulinemia

A

recurrent infections, esp enterovirus

small or absent lymph nodes or tonils

34
Q

Chediak-Higashi Syndrome

A

partial albinism
ataxia
giant granules in neutrophils

35
Q

Common Medications for SJS

A

sulfonamides

36
Q

treatment of linear IgA bullous dermatosis

37
Q

X-linked immunodeficiencys

A

Bruton

chronic granulomatous def

38
Q

DRESS can be associated with re-activation of

39
Q

DiGeorge- abnormality of what cells

40
Q

Treatment of Group C or G Streptococcal Pharyngitis?

A

Yes, PCN for symptoms (not ARF)

41
Q

Erythasma

A

reddish to brown plaques in axillae, groin in obese individuals
corynebacterium, rx w/ macrolide

42
Q

X linked recessive icthyosis associated with

A

GU abnormalities

43
Q

Severe seborrheic dermatitis, consider

A

langerhans

44
Q

port wine stains of LE, think

A

Klippel-Treneauy Syndrome

45
Q

Nevus of Ota associated with risk of

A

ocular and cutaneous melanoma

46
Q

TNPM has what cells?

A

Neutrophils

47
Q

Large Facial Hemangiomas, associated syndrome

A

PHACES

posterior fossa abn, hemangioma, arterial abnormalities, cardiac, eye, and sternal defects

48
Q

Incontineta Pigmenti

A

X-linked dominant
blistering that follows line of blaschko
delayed eruption of teeth

49
Q

Cells Associated with Erythema Toxicum Neonatum

A

Eosinophils

50
Q

IgA Linear Bullous Dermatosis Clinical Course

A

Rx with dapsone

usually resolves by puberty

51
Q

PLEVA

A

browning/reddish bumps, often misdiagnosed as varicella

Rx with erythromycin

52
Q

Abnormal DHR test

A

Chronic Granulomatous Disease

53
Q

Absent serum CH50

A

Complete Deficiency

54
Q

Giant granules in neutrophils

A

Chiedak-Higashi

Peds Boards (21 decks)

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