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MSK Biweekly Exam 1 > Al-Mehdi NM Pharmacotherapeutics > Flashcards

Al-Mehdi NM Pharmacotherapeutics Flashcards

1
Q

Autoimmune disorder resulting in loss of presynaptic neuronal VGCCs and impaired ACh release

A

Lambert-Eaton Syndrome

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2
Q

patient presents with weakness what do you automatically think

A

muscle weakness

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3
Q

fluctuating muscle weakness sign of

A

neuromuscular junction problems

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4
Q

AchE in synapse of NMJ allows for what to be recycled

A

choline

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5
Q

in the spinal cord, NOT NMJ, what prevents GABA release by degrading synaptobrevin

A

Tetanus toxin

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6
Q

at the NMJ level, what degrades SNAP-25 and syntaxin causing no release of Ach

A

Botulinum toxin

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7
Q

Nm receptor blockers end in

A

“curonium”

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8
Q

Nm receptor agonists

A

succinylcholine
acetylcholine
nicotine

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9
Q

Nm only location in the body

A

NMJ

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10
Q

autoimmune disease targeting VGKC and increase in Ach release

A

neuromyotonia

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11
Q

condition where your muscles are unable to relax after contraction

A

myotonia

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12
Q

NMJ disorders highest prevelance in what populations

A

younger women and older men

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13
Q

this can lead to myasthenia gravis and targets Nm

A

Thymoma

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14
Q

this is associated w/ Lambert-Eaton syndrome and targets p/q type VGCC

A

small cell lung cancer

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15
Q

features include: painless, fluctuating muscle weakness and Ptosis; weakness increases with continued activity

A

Myasthenia Gravis

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16
Q

other main clinical features include dysarthria and myasthenic sneer

A

Myasthenia Gravis

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17
Q

defined as the need for ventilator support for respiratory muscle weakness

A

myasthenic crisis

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18
Q

ocular findings of this include shifting ptosis (from one eye to the other)

A

Myasthenia Gravis

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19
Q

To diagnose MG:

A

AChE inhibitors

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20
Q

AChE inhibitors used to diagnose MG:

A

Neostigmine and Edrophonium

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21
Q

everything slows down on EMG

A

MG

22
Q

amplitude increases on EMG for this

A

Lambert-Eaton syndrome

23
Q

drug used to manage MG

A

Pyridostigmine bromide

24
Q

surgery to perform for MG

A

thymectomy

25
Q

type of drugs used to treat MG

A

immunosuppressants

26
Q

Cyclosporine and Tacrolimus inhibit what

A

calcineurin (decrease in IL-2)

27
Q

monoclonal Ab against CD20 (inhibits B cells)

A

Rituximab

28
Q

Eculizumab is monoclonal antibody against what

A

C5 (MAC)

29
Q

glucocorticoid that inhibits B cells

A

Prednisone

30
Q

Azathioprine and Mycophenolate Mofetil MoA

A

inhibit B cell and have cytotoxic effects

31
Q

1st line immunosuppressant drugs for MG:

A

Azathioprine and Prednisone

32
Q

lower extremity weakness and dry mouth features of

A

Lambert-Eaton syndrome

33
Q

small cell lung carcinoma (SCLC) has antibodies against what transcription factor

A

SOX1

34
Q

test for LEMS

A

triple timed up and go test

35
Q

Lambert-Eaton Syndrome isassociated w/ what carcinoma

A

small cell lung carcinoma

36
Q

MoA for Amifampridine (3,4-Diaminopyridine) and used to treat…

A

opens VGCC and increases Ach release; used to treat LEMS

37
Q

cause of denervation atrophy (important for trophic function of muscle)

A

non-vesicular Ach release

38
Q

Nm blockers that are used for general anesthetics end in

A

-curium

39
Q

after surgery, paralysis is reversed by IV what

A

Neostigmine

40
Q

neuromuscular blockade drug that can lead to malignant hyperthermia

A

succinylcholine

41
Q

caused by mutation in RyR and use of succinylcholine and halothane

A

malignant hyperthermia

42
Q

increase in end-tidal CO2 during ventilation is a sign of what

A

malignant hyperthermia

43
Q

to treat malignant hyperthermia

A

Dantrolene

44
Q

velocity-dependent increase in resistance to passive movement

A

spasticity

45
Q

chronic spasticity

A

contracture

46
Q

sign of UMN lesion

A

spasticity

47
Q

Tizanidine and Baclofen are what

A

antispastic drugs

48
Q

alpha2 agonist used as antispastic drug; inhibits release of Ach

A

Tizanidine

49
Q

GABAb agonist used as antispastic drug

A

Baclofen

50
Q

GABA a agonist used as antispastic drug

A

benzodiazepines

51
Q

adverse effects of antispastic drugs

A

sedation

52
Q

one of the most prescribed drugs in the ED used to treat muscle spasm caused by local tissue trauma or muscle strains

A

Cyclobenzaprine

MSK Biweekly Exam 1 (11 decks)

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