AKI Drugs

Question 1

Usually safe to continue in AKI (6)

Answer 1

• Paracetamol
• Warfarin
• Statins
• Aspirin (at a cardioprotective dose of 75mg od)
• Clopidogrel
• Beta-blockers

Question 2

Should be stopped in AKI as may worsen renal function (5)

Answer 2

• NSAIDs (except if aspirin at cardiac dose e.g. 75mg od)
• Aminoglycosides
• ACE inhibitors
• Angiotensin II receptor antagonists
• Diuretics

Question 3

May have to be stopped in AKI as increased risk of toxicity (but doesn’t usually worsen AKI itself) 3

Answer 3

• Metformin
• Lithium
• Digoxin

Question 4

what drug stabilises cardiac membrane in hyperkalaemia?

Answer 4

• Intravenous calcium gluconate

Question 5

what drugs causes short-term shift in potassium from extracellular to intracellular fluid compartment in hyperkalaemia? 2

Answer 5

• Combined insulin/dextrose infusion
• Nebulised salbutamol

Question 6

what drugs remove potassium from the body in hyperkalaemia? 3

Answer 6

• Calcium resonium (orally or enema)
• Loop diuretics
• Dialysis