Adrenal and Pituitary Function Test Flashcards
Cortisol level of horses during midnight
3.0 μg/dL
Cortisol level of horses during 8 AM to 4 PM
4.5-5 μg/dL
How many percent of dog’s cortisol is bound to transcortin?
40%
How many percent of dog’s cortisol is bound to albumin?
50%
Half-life of cortisol in dogs?
1.5 hours
Cortisol is removed in the plasma by which tissues?
Hepatocytes, minimally by kidney
It is a rare case of hypocortisolemia without concurrent hypoaldosteronemia, hyponatremia or hyperkalemia reported
atypical primary hypoadrenocorticism or selective cortisol deficiency
An antifungal treatment which inhibits steroid synthesis in dogs and cats leading to hypocortisolemia
ketoconazole (and also trilostane)
Identify the chemistry profile of a dog with hypocortisolemia
hyponatremia, hypochloremia, hyperkalemia, hypercalcemia, hypoglycemia, azotemia
Dogs with hypocortisolemia may be supported by another laboratory findings from urinalysis
low specific urine gravity with azotemia
ACTH concentration is expected to have increase value in these conditions
a. PDH
b. Primary hypoadrenocorticism
c. Ectopic production of ACTH
d. After stressful stimuli
Increase or Decrease. Dogs with primary hypoadrenocorticism after injection of CRH.
INCREASE
ACTH concentration is expected to have decrease value in these conditions
a. FAN
b. Secondary hypoadrenocorticism
c. After dexamethasone injection
d. Therapeutic treatment with glucocorticoid steroids
INCREASE or DECREASE. Cortisol level in dogs with secondary hypoadrenocorticism after injection of CRH.
Decrease
In which months are Plasma ACTH concentration greater in horses and ponies?
September
True or false: Clinical use of ACTH is hampered by instability of ACTH and expensive dry-ice shipments.
True
A screening test for PDH and FAN
LDDST
A stimulation suppression test highly sensitive to FAN
LDDST
A test that may differentiate PDH from FAN after hyperadrenocorticism is diagnosed
HDDST
Increase or suppress. LDDST in hyperadrenocorticism caused by PDH or ectopic production of ACTH.
May or may not suppress ACTH therefore may or may not reduced cortisol level
Increase or Decrease. LDDST in hyperadrenocorticism caused by FAN.
Not expected to decrease cortisol.
Increase or suppress. HDDST in animals with hyperadrenocorticism caused by PDH.
Suppress ACTH therefore DECREASE cortisol secretion.
Increase or decrease. HDDST in animals with hyperadrenocorticism caused by FAN.
Not expected to decrease.
Increase or decrease. HDDST in dogs with nonadrenal illness.
Cortisol expected to decrease
True or False. Cats may escape the suppressive effects of dexamethasone faster than dogs
true.
Increase or Decrease. Hyperadrenocorticism cause by PPID after dexamethasone administration.
not decreased
In horses with PPID, maximal suppression of postdexamethasone was seen after how many hours of administration?
8-12 hours
ACTH gel stimulation test is not recommended as a diagnostic test for these species
equine PDH
Some dogs with non adrenal disorders have high aldosterone and this high concentration are probably related or due to?
Hypovolemia or decreased effective blood volume
Aldosterone concentrations in dogs with PDH have lower concentration. Explain the cause.
Because of under chronic ACTH stimulation, some of the aldosterone secreting cells converted into cortisol secreting cells.
Increase or decrease. Aldosterone concentration in dogs with FAN.
Increase.
Increase or decrease. Blood eosinophil in healthy dogs with elevated blood cortisol during thorn test.
Decrease
Increase or decrease. Neutrophil to lymphocyte ratio in healthy dogs if blood cortisol increases during modified thorn test.
Increase
Failure to see a decrease in eosinophil and failure to see an increased neutrophil to lymphocyte ratio after administration of ACTH suggest the presence of which condition?
Hypoplastic or atrophied adrenal glands
Increase or decrease. Progesterone concentration in dogs and cats with FAN.
Increase
can be used to monitor destruction of adrenocortical tissue
ACTH stimulation test
can be used to monitor the effectiveness of trilostane treatment of PDH
ACTH stimulation test
