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AA4 Clinical Vet Pathology > Adrenal and Pituitary Function Test > Flashcards

Adrenal and Pituitary Function Test Flashcards

1
Q

Cortisol level of horses during midnight

A

3.0 μg/dL

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2
Q

Cortisol level of horses during 8 AM to 4 PM

A

4.5-5 μg/dL

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3
Q

How many percent of dog’s cortisol is bound to transcortin?

A

40%

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4
Q

How many percent of dog’s cortisol is bound to albumin?

A

50%

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5
Q

Half-life of cortisol in dogs?

A

1.5 hours

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6
Q

Cortisol is removed in the plasma by which tissues?

A

Hepatocytes, minimally by kidney

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7
Q

It is a rare case of hypocortisolemia without concurrent hypoaldosteronemia, hyponatremia or hyperkalemia reported

A

atypical primary hypoadrenocorticism or selective cortisol deficiency

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8
Q

An antifungal treatment which inhibits steroid synthesis in dogs and cats leading to hypocortisolemia

A

ketoconazole (and also trilostane)

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9
Q

Identify the chemistry profile of a dog with hypocortisolemia

A

hyponatremia, hypochloremia, hyperkalemia, hypercalcemia, hypoglycemia, azotemia

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10
Q

Dogs with hypocortisolemia may be supported by another laboratory findings from urinalysis

A

low specific urine gravity with azotemia

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11
Q

ACTH concentration is expected to have increase value in these conditions

A

a. PDH
b. Primary hypoadrenocorticism
c. Ectopic production of ACTH
d. After stressful stimuli

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12
Q

Increase or Decrease. Dogs with primary hypoadrenocorticism after injection of CRH.

A

INCREASE

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13
Q

ACTH concentration is expected to have decrease value in these conditions

A

a. FAN
b. Secondary hypoadrenocorticism
c. After dexamethasone injection
d. Therapeutic treatment with glucocorticoid steroids

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14
Q

INCREASE or DECREASE. Cortisol level in dogs with secondary hypoadrenocorticism after injection of CRH.

A

Decrease

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15
Q

In which months are Plasma ACTH concentration greater in horses and ponies?

A

September

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16
Q

True or false: Clinical use of ACTH is hampered by instability of ACTH and expensive dry-ice shipments.

A

True

17
Q

A screening test for PDH and FAN

A

LDDST

18
Q

A stimulation suppression test highly sensitive to FAN

A

LDDST

19
Q

A test that may differentiate PDH from FAN after hyperadrenocorticism is diagnosed

A

HDDST

20
Q

Increase or suppress. LDDST in hyperadrenocorticism caused by PDH or ectopic production of ACTH.

A

May or may not suppress ACTH therefore may or may not reduced cortisol level

21
Q

Increase or Decrease. LDDST in hyperadrenocorticism caused by FAN.

A

Not expected to decrease cortisol.

22
Q

Increase or suppress. HDDST in animals with hyperadrenocorticism caused by PDH.

A

Suppress ACTH therefore DECREASE cortisol secretion.

23
Q

Increase or decrease. HDDST in animals with hyperadrenocorticism caused by FAN.

A

Not expected to decrease.

24
Q

Increase or decrease. HDDST in dogs with nonadrenal illness.

A

Cortisol expected to decrease

25
Q

True or False. Cats may escape the suppressive effects of dexamethasone faster than dogs

A

true.

26
Q

Increase or Decrease. Hyperadrenocorticism cause by PPID after dexamethasone administration.

A

not decreased

27
Q

In horses with PPID, maximal suppression of postdexamethasone was seen after how many hours of administration?

A

8-12 hours

28
Q

ACTH gel stimulation test is not recommended as a diagnostic test for these species

A

equine PDH

29
Q

Some dogs with non adrenal disorders have high aldosterone and this high concentration are probably related or due to?

A

Hypovolemia or decreased effective blood volume

30
Q

Aldosterone concentrations in dogs with PDH have lower concentration. Explain the cause.

A

Because of under chronic ACTH stimulation, some of the aldosterone secreting cells converted into cortisol secreting cells.

31
Q

Increase or decrease. Aldosterone concentration in dogs with FAN.

A

Increase.

32
Q

Increase or decrease. Blood eosinophil in healthy dogs with elevated blood cortisol during thorn test.

A

Decrease

33
Q

Increase or decrease. Neutrophil to lymphocyte ratio in healthy dogs if blood cortisol increases during modified thorn test.

A

Increase

34
Q

Failure to see a decrease in eosinophil and failure to see an increased neutrophil to lymphocyte ratio after administration of ACTH suggest the presence of which condition?

A

Hypoplastic or atrophied adrenal glands

35
Q

Increase or decrease. Progesterone concentration in dogs and cats with FAN.

A

Increase

36
Q

can be used to monitor destruction of adrenocortical tissue

A

ACTH stimulation test

37
Q

can be used to monitor the effectiveness of trilostane treatment of PDH

A

ACTH stimulation test

AA4 Clinical Vet Pathology (14 decks)

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