AD

Question 1

What is AD gen char

Answer 1

Def: MC dementia that affects memory, higher learning, reasoning, behavior and emotion
W>M
Cause:
tau -> neurofibrillary tangles -> nerve cell death
amyloid precursor protein -> plaques form from clumps -> block cell-to-cell signaling at synapses -> activate immune system to inflame and devour disabled cells

Question 2

What is major neurocognitive disorder diagnostic criteria (DSM-5)

Answer 2

• Evidence of significant cognitive decline from previous level of performance in cognitive decline
• cognitive deficits interfere with everyday activities
• cognitive deficits do not occur exclusively in the context of delirium
• cognitive deficits not explained by another mental disorder

Question 3

What is mild neurocognitive disorder diagnostic criteria (DSM-5)

Answer 3

• same as major neurocognitive but modest cognitive decline

Question 4

What does apolipoprotein E have to do with AD

Answer 4

APOE-4 3-5 x increased risk of AD
APOE-2 2x protection from AD
APOE-3 MC

Question 5

AD diagnosis

Answer 5

• criteria met for mild or major neurocognitive disorder
• insidious onset and gradual progression of impairment in cognitive domains
• criteria met for probable or possible AD
• disturbance not better explained by other disease

Question 6

What is probable AD

Answer 6

• evidence of genetic mutation
• clear evidence of decline in memory and learning
• steady, progressive decline in cognition
• no mixed etiology

Question 7

What is possible AD

Answer 7

• no evidence of genetic mutation
• clear evidence of decline in memory and learning
• steady, progressive decline in cognition
• no mixed etiology

Question 8

What is testing for AD

Answer 8

Mini-mental status testing (MMSE)

CAM

Question 9

What is Dgx workup for AD

Answer 9

History
Physical
MMSE
Neuropsychological testing
Depression Assessment