ACS and AMI - Therapy

Question 1

thrombolytic agents can be divided into two categories, what are they

Answer 1

fibrin-specific agents

non-fibrin specific agents

Question 2

what are examples of fibrin specific thrombolytic agents

Answer 2

alteplase
reteplase

(these produce limited plasminogen conversion in the absence of fibrin)

Question 3

what is an example a of non-fibrin specific agent

Answer 3

streptokinase

Question 4

what are contraindications to thrombolysis treatment

Answer 4

prior intracranial hemorrhage
recent ischemic stroke
active bleeding

Question 5

if there is no evidence of a STEMI what is the standard treatment

Answer 5

1. cardiac monitor
2. O2 if needed
3. chest pain?4.GNT/opiates/nitrates
4. aspirin
5. clopidogrel
6. LMWH
7. beta blockers

Question 6

what is prasugrel

Answer 6

platelet inhibitor

Question 7

what is ticagrelor

Answer 7

platelet aggregation inhibitor

Question 8

what is GIIbIIIa

Answer 8

a class of antiplatelet angents

Question 9

Aspirin is a potent inhibitor of what

Answer 9

platelet thromboxane production

Question 10

clopidogrel is always used in combination with what other drug, why

Answer 10

Aspirin

Relative risk reduction of 21% when used together with aspirin.

Question 11

what percentage of the population show clopidogrel resistance

Answer 11

14%

Question 12

what are 2 strengths of Prasugrel compared to Clopidogrel

Answer 12

induced platelet aggregation more rapidly, more consistently