Acne vulgaris Flashcards by Nadeem Marghoob | Brainscape

Q

Pathogenesis of acne:

A

P. acnes overgrowth
sebum overproduction
abnormal keratinization
inflammation

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Q

Androgents (especially. ____ and _____ cause increased growth of sebaceous glands which can worsen acne.

A

DHT and testosterone

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Q

What are the mechanisms that P. acnes bacteria can cause acne?

A

produces lipases that breakd down triglycerides in sebum into FFAs, which are comedogenic and proinflammatory
activates TLR-2 which induces inflammation

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