ACID AND BASE BALANCE Flashcards
contains only a single proton which is not orbited by any electron, it is the smallest ionic particle
Hydrogen ion
It is difficult to determine the acid-base status in the ECF by direct methods. So, an indirect method is followed by using
Henderson-Hasselbalch equation
are derived from πΆπ2. Large quantity of πΆπ2 is produced during the metabolism of carbohydrates and lipids
Volatile acids
are produced during the metabolism of other nutritive substances
such as proteins
Non-volatile acids
sulfuric acid is produced during the metabolism of sulfur containing amino acids such as
cysteine and metheonine
An acid-base buffer system is the combination of a weak acid
protonated substance
Types of Buffer System 3
ο· Bicarbonate buffer system
ο· Phosphate buffer system
ο· Protein buffer system.
is present in ECF (plasma).
Bicarbonate buffer system
prevents the fall of pH in a fluid to which a strong acid like hydrochloric acid (HCl) is added.
Bicarbonate buffer system
This system consists of a weak acid, the dihydrogen phosphate in the form of sodium dihydrogen phosphate and the base, hydrogen phosphate in the form of disodium hydrogen phosphate
Phosphate Buffer System
is more powerful than bicarbonate buffer system as it has a pK of 6.8, which is close to the pH of the body fluids, i.e. 7.4.
Phosphate buffer system
are present in the blood; both in the plasma and erythrocytes.
Protein buffer systems
is the reduction in pH below normal range
Acidosis
is the increase in pH above the normal range.
Alkalosis
the acid-base disturbances are: 4
- Respiratory acidosis
- Respiratory alkalosis
- Metabolic acidosis
- Metabolic alkalosis