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AII 3 > Abx > Flashcards

Abx Flashcards

1
Q

Prophylaxis

A

Prevention of disease- taking abx before surgery or procedure to prevent infection

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2
Q

Empiric therapy

A

Treatment with abx before the specific organism has been identified

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3
Q

Definitve therapy

A

abx use based on identified organism

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4
Q

colonization

A

growth of microorganisms in a particular body site

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5
Q

infection

A

disease caused by microorganism

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6
Q

Contamination

A

introduction of pathogens into normally clean and sterile environment

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7
Q

bactericidal

A

capable of killing bacteria

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8
Q

bacteriostatic

A

inhibition or retardation of growth of bacteria with out their destruction

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9
Q

bactericidal drugs

A

Kill bacteria- peniciilans

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10
Q

Clavulanic acid

A

Beta lactam agonist- restores function of antibiotic by addressing resistance

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11
Q

Aminoglycosides- Mech of action

A

Ribosomal protein synthesis inhibitor- bacteriostatic- can be cidal with increased concentration

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12
Q

Aminoglycosides- Types

A

End in mycin- gentomycin, streptomycin, neomycin

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13
Q

Aminoglycosides- Spectrum of activity

A

Gram -Including Pseudomoas aerug- severeSynergistic with beta lactam for gram +

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14
Q

Beta Lactams

A

Penicillin, Cephalosporins, carbapenem & vancomycin

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15
Q

Penicillin- Mech of action

A

Inhibit cell wall synthesis leads to cell lysis

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16
Q

Penicillins- Names

A

End in cillin- penicillin G, ampicillin, amoxicillin

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17
Q

Penicillins- Uses

A

Gram +Streptococci

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18
Q

Peinicillin G, VK

A

Drug of choice for N Meningitis, syphilis

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19
Q

Ampicillin & amoxicillin

A

Gram +Extended spectrumRespiratory infectionsStreptococci, enterococci

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20
Q

Cephalosporins- mech of action

A

Beta lactam antibiotics- inhibit cell wall synthesis

21
Q

1st generation cephalosporins

A

cephlexn, cefazolin

22
Q

1st generation cephalosporin- spectrum of activity

A

Gram +: Strept, MSSA some Gram -: E.coli, Klebisselaskin & resp infections

23
Q

2nd generation Cephalosporin- spectrum of activity

A

Gram +: Strept, MSSAGram - : Good coverage- B fragilis

24
Q

2nd generation cephalosporin- drug names

A

cefuroxime, cefotetan, ceforitin

25
Q

3rd generation cephalosporins- drug names

A

ceftriaxone, cefotaxime, ceftzidime

26
Q

3rd generation cephalosporins- spectrum of activity

A

Resp & serious infectionsPenetrates CSFGram +: Strept, MSSAGram - Very good- pseudomonas

27
Q

4th generation cephalosporins- drugs

A

cefepime

28
Q

4th generation cehpalosporins- spectrum of activity

A

Gram +: Strept, MSSAGram - excellent- through Pseudomondas

29
Q

Monobactam- mechanism of action

A

Disrupt cell wall synthesis- baceriacidal

30
Q

Monobactam- drug

A

aztreonam

31
Q

Monobactam- spectrum of activity

A

Gram -Up to pseudomondas

32
Q

Carbapenem- mech of action

A

Beta lactam- disrupt cell wall synthesis

33
Q

Carbapenem- Drugs

A

End in penem- imipenem

34
Q

Vancomycin- Mech of action

A

Inhibits cell wall synthesis- beta lactam

35
Q

Vancomycin- Spectrum of activity

A

Drug of choice for MRSAStrept, Staph, EnteroNo Gram -

36
Q

Macrolides- drugs

A

erythromycin, clarithromycin, azithromycin

37
Q

Macrolides- Mech of activity

A

Ribosomal inhibition- bacteriostatic

38
Q

Macrolide- Spectrum of activity

A

Gram +Chlamydia & syphallisAtypical respiratory infections: Legionella, pneumoniae

39
Q

Tetracyclines- Drugs

A

end in cycline- doxycycline, tetracycline, mincycline

40
Q

Tetracycline- Mech of action

A

Ribosomal protein synthesis inhibitor- bacteriostatic

41
Q

Tetracycline- spectrum of activity

A

Gram + strept & MSSAWeak Gram -A typical respiratory infections

42
Q

Quinolones- Drugs

A

“floxacin”ciprofloxacin, norfloxacin

43
Q

Quinolones- Mech of action

A

Inhibit DNA synthesis- bacteriostatic

44
Q

Sulfa Drugs

A

Trimethoprim-sulfamethoxazole

45
Q

Sulfa- Mech of action

A

Inhibit folic acid synthesis- formation of essential cofactor- bacteriostatic

46
Q

Sulfa- Spectrum of activity

A

Gram + Strept, MSSAGram - Enterobacteriacae

47
Q

Anaerobic agents

A

Clindamycin, metronidazole, chloramphenicol

48
Q

Anaerobic- mech of action

A

Inhibition of ribosome- bacteriostatic

AII 3 (13 decks)

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