Absestosis Flashcards
what is asbestosis
Asbestosis = diffuse interstitial fibrosis with asbestos bodies (golden brown, fusiform or beaded rods with a translucent center) due to inhalation of asbestos particles in workers engaged in mining, pipes, brakes, insulation and boilers.
Initially the absestosis involves which part of the lung
Initially, involvement of lower lobes of the lung pleurally
what are absestos
Asbestos fibres are crystalline hydrated silicates; their different forms (size, shape, solubility) and concentration affect their disease-causing capabilities
Absbestosis are phagocytosed by what?
Asbestos fibres are phagocytosed by macrophages and activate the inflammasome, stimulating the release of proinflammatory factors and fibrogenic mediators
The absestos in contract to other dusts can act as what?
In contrast to other dusts, can also act as a tumor initiator and tumor promoter
List the two type of fibers for asbestosis
Two types of fibers are:
* Serpentine (curly and flexible fibres, chrysotile): These account for most of the asbestos used in industry.
* Amphibole (straight, stiff and brittle fibres, crocidolite, amosite, actinolyte): These are more pathogenic than chrysotiles, particularly with respect to induction of mesotheliomas
The pleural plaques do not contain what?
Asbestos bodies
what is pleural plaque
It is the most common manifestation of asbestos exposure and is composed of well circumscribed plaque of dense collagen containing calcium. They are usually asymptomatic and develop on anterior and posteriolateral parts of parietal pleura and over the diaphragm
what is mean by bronchogenic cancer
Most common cancer associated with asbestos whose risk is increased with concomitant smoking
What is ment by mesothelioma
Localised asbestos fibers in the lung close to the mesothelial layers increases the risk of development of pleural and peritoneal mesothelioma. Cpncomitant smoking does not increase the risk of mesothelioma. it is the most specific cancer associated with asbestosis inhalation
List lesions with asbestosis
Pleural plaque
Interstitial fibrosis
Bronchogenic cancer
Mesothelioma
Pleural effusion
Laryngeal and colon cancer
The inhaled long asbestosis fibers become what?
coated with iron and calcium, then is called aferruginous body,several of which are seen here with a Prussian blue iron stain.
The ingestion of asbestos fibers by macrophages sets off a ?
Ingestion of these fibers by macrophages sets off a fibrogenic response through release of cytokine growth factors that promote continued collagen deposition by fibroblasts.
