A6- Medical Disorders in Pregnancy Flashcards
What are the three types of hypertension in pregnacy?
- Hypertension that exists before pregnancy (chronic hypertension)
- Hypertension that develops during pregnancy without proteinuria (gestational hypertension)
- Hypertension that develops during pregnancy with proteinuria (pre-eclampsia)
Is chronic hypetension high risk in pregnancy ?
yes or no
yes
What is gestational hypertenion?
Are there signs of preoteinuria?
Bichemistry?
Growth of baby?
- New hypertension after 20 weeks
- Not accompanied by proteinuria
- Normal biochemistry
- Normally grown baby
- Outcomes are good and it should not be treated!
can gestational hypertension lead to pre- eclampsia?
Yes
at least 30% of women who present with gestational hypertension will go on to develop pre-eclampsia
What is pre-eclampsia?
Defined as hypertension and proteinuria arising after the 20th week of gestation in a previously normotensive woman
Pre eclampsia?
How common is it?
Who are affected?
- Common disorder; occurs in ~3% of the UK antenatal population
- Affects all ages, ethnic and socioeconomic groups
What are surviving infants of pre eclampsia, risk of getting long term?
risk of long-term complications of intrauterine hypoxia and pre-maturity in addition to heart disease and diabetes
Maternal death rate for pre eclampsia?
Remains a leading cause of maternal death
Hypertensive disorders of pregnancy account for nearly 18% of all maternal deaths world-wide, with an estimated 62 000–77 000 deaths per year
Who is at risk of pre-eclampsia?
- First mothers
- Family history
- Older mothers
- Obese
- Multiple pregnancies
• Pre-existing medical conditions:
Diabetes
Chronic hypertension
Antiphospholipid syndrome
Aetiology of pre-eclampsia
Overview
Genetic Predisposition
Abnormal Immunological Response
Deficient Trophoblast Invasion
Hypoperfused Placenta
Circulating Factor(s)
Vascular Endothelial Cell Activation
Clinical Manifestations of Disease
What are the geentic factors that relate to pre eclampsia?
• Affected first degree relative confers a 25% chance of developing pre-eclampsia
polygenic disorder with some fetal contribution
• Candidate genes of interest include: Factor V Leiden, Prothrombin gene variant, MTHFR, Angiotensinogen (235Thr)
How do partners affect pre eclampsia
- Previously uncomplicated pregnancy with the same partner confers a protective effect
- Changing partners increases risk
- Changing partners after an affected pregnancy reduces risk
- A man who has fathered one pre-eclamptic pregnancy is nearly twice as likely to father another affected pregnancy with a different partner
Do the following statements increase or decrease the risk of pre eclampsia?
- Exposure to paternal antigens in seminal fluid
- Barrier contraceptives associated with
- Long period of cohabitation associated with
- Exposure to paternal antigens in seminal fluid decreases risk
- Barrier contraceptives associated with increased risk
- Long period of cohabitation associated with decreased risk
What do sprial arteries look like in non pregnant state?
It has a thick musclar smooth muscle coat and it spirals so that the blood supply to the endometrium can be cut down during menstruation?
What do spiral arteries look like in pregnancy?
In early pregnancy, trophoblast from the invading embryo and placenta modify the spiral ateries.
They invade fown the lumen and intersititally from th eisfe.
They replace the smooth muscle with spongy trophoblast and that means that the spiral arteries dilate. THey lose a lot of their spirals.
Lumen becomes very wide and they give rise to a high capacitance, low resistance circulation which allows copious amounts of nutrients and gaseous exchange to occur between the mother and foetus via the placenta