A2- The Pathology of Lung Cancer

Question 1

Examples of non small cell lung cancer?

Answer 1

Squamous
Adenocarinomas
Non small cell lung cancer- not otherwised specified

Question 2

For therapy with tyrosine kinase inhibitors, what singke genomic drivers do we target:

Answer 2

EGFR, ALK, ROS1, BRAF, NTRK, MET, RET, HER2

Question 3

For therapy with immune modulators, what single genomic drivers do we target:

Answer 3

PD-L1 expression, tumour mutational burden (TMB)

Question 4

How can we lung cancer profile?

Answer 4

Immunochemistry
Flurescent in situ hybridisation
Single gene testing
Sequencing