A10. Indirect sympathomimetics. Selective α1 -agonists. Selective alpha 2-agonists and drugs acting on the imidazoline receptors.

Question 1

List the indirect sympathomimetics.

Answer 1

“Monoamine releasers”, presynaptic stimulation. except tyramine, not metabol. by COMT or MAO long DOA

1. Psychostimulants: (Meth)amphetamine, Dexedrine, Methylphenidate, MDMA
2. Ephedrines: Ephedrine, Pseudoephedrine, Norephedrine.
3. Tyramine

Question 2

List the alpha 1 agonists.

Answer 2

1. Selective alpha 1 agonists: Phenylephrine
2. Non-selective alpha antagonists: Oxymetazoline, Xylometazoline, Naphazoline.

Question 3

List the alpha 2 agonists.

Answer 3

Drugs act on imidazoline R.

1. Clonidine
2. Guanfacine+ Guanabenz
3. Moxonidine+ Rilmenidine
4. Alpha methyl DOPA
5. Tizanidine

Question 4

What are the 3 main classes of Imidazoline R?

Answer 4

3 main classes:

I1:

I2:

I3: