A1. Pharmacodynamics I (Molecular targets of drugs. Drug receptors. Receptor theory.) Flashcards
Define Pharmacodynamics? What is it?
Pharmacodynamics is how the drug acts on the body (therapeutic effects, side effects).
What is Pharmacokinetics?
How body responds to the drug (i.e. absorption, distribution, metabolism, excretion)
List the Molecular targets of drugs.
- Voltage-gated ion channels
- Intracellular receptors
- Enzymes
- Transporters
- Nucleic acids
- Assorted atypical drugs
- Membrane receptors
- Structural proteins
[can rearrange it and use mnemonic VIETNAMS]
List the Drug receptors?
G protein couple R : many drugs act on GPCRS
- Adrenergic: catecholamines, beta blockers + many others
- Muscarinic: antimuscarinic (atropine). cholinomimetic
- Dopamine: Bromocriptine
- Histamine: Anti histamine
- Vasopressin
- GABA-BR
- ACTH-R
- PTH-R
- Glycoprotein R: (FSH, LH, TSH)
- Most neuropeptide R: opioid, angiotensin, bradykinin,CCK,NPY, oxytocin)
What is the Receptor theory?
- A drug works by acting as a ligand on a specific receptor.
- R = specific, saturable + infinte in #’s
Give examples of membrane receptors.
(GPCRs, TKs, Ligand-gated ion channels)
Give examples of intracellular receptors.
(steroid receptors, nuclear receptors, PPAR-gamma)
Give examples of Voltage-gated ion channels.
(e.g. calcium channel blockers)
Give examples of enzymes.
usually inhibited (e.g. statins, aspirin, MAOI)
Give examples of Transporters
(e.g. SSRI/SNRIs, cocaine)
Give examples of Structural proteins
(e.g. integrin antagonist to disrupt T cells in a MS drug)
Give examples of Nucleic acids targets.
Nucleic Acids (e.g. cancer drugs)
Give examples of Assorted atypical drugs.
antacids (provide base), activated charcoal (binds to prevent absorption)
