(A) Schizophrenia- Sutherland Flashcards
What is the number one predictor of disability in schizophrenia patients?
Cognitive Decline
When is onset of schizophrenia?
Onset in early adulthood
-probably had years of vague “prodromal” symptoms (depression, anxiety)
Hallmark symptom of schizophrenia?
“Something just changed in the person”
Is schizophrenia more common in men or women?
MEN
Largest difference between biopolar and schizophrenia?
Bipolar is epsiodic
Schizophrenia is NOT
Symptoms of Schizophrenia?
Cognitive impairment
Perceptual and thought disturbance
affective symtoms
Social function impairment
What are the affective symptoms of schizophrenia?
"negative" symptoms Flat affect - blend into backgroug withdrawal Social avoidance poor motivation Agitation
What cognitive impairmenta are the central deficit in schizophrenia?
Poor working memory
Poor attention
Impaired executive function
What is the lifespan deficit for people with schizophrenia?
high mortality rate!
20 YEAR LIFESPAN DEFICIT
What types of hallucinations are most common in schizophrenia?
- Auditory
- Visual
- Other
What are the perceptual and thought disturbances found in schizophrenia?
Hallucinations
Delusions (paranoid, nihilistic)
Odd behavior
Poverty of thought - brain is filled with hallucinations and delusions so they cannot think clearly
What effect does marijuana correlate with schizophrenia?
Marijuana use makes you 3x more likely to develop schizophrenia
Defective COMT metabolism
What effect does marijuana correlate with schizophrenia?
Marijuana use makes you 3x more likely to develop schizophrenia
Defective COMT metabolism**
Pathophysiology of schizophrenia?
Increased brain dopamine **(and increased 5HT)
Loss of brain mass
Loss of brain connections (white matter)
How do you treat schizophrenia?
****Dopamine blockers!!!!
Second generation anti-psychcotic
