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Oncology > 9 - Radiation > Flashcards

9 - Radiation Flashcards

1
Q

Gray

A

Absorption of on ejoule of radiation energy per one kilogram of matter

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2
Q

Vast majority of tumors treated with radiation will die due to

A

Necrosis

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3
Q

The four R

A

Repair, repopulation, redistribution, reoxygenating

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4
Q

Which tumor can u see response rlly quickly

A

Lymphoma

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5
Q

The most important R

A

Repair

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6
Q

Repair can happen in both

A

Tumor and normal cells

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7
Q

What % of normal cells are recovered due to compensatory proliferation

A

50 - 60

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8
Q

Redistribution has to do with

A

Cell cycles

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9
Q

What cell phase is cell most sensitive to radiation

A

G2/M

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10
Q

What two blocks of cell cycle

A

G1 S and G2 M

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11
Q

What % of tumors have hypoxia

A

50

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12
Q

Oxygenated cells are more sensitive to

A

Radiation

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13
Q

Acute hypoxia

A

Reopening of closed capillaries

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14
Q

Chronic hypoxia

A

Oxygenated cells die allowing oxygen to diffuse to new areas

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15
Q

Definitive radiation

A

Long term tumor control, daily treatments, small daily dose

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16
Q

Palliative radiation

A

Shorter survival times, weekly treatments, high daily dose

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17
Q

Acute side effects of radiation related to

A

Stem cell damage

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18
Q

Acute side effects starts

A

During the third week of treatment

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19
Q

Acute side effects last

A

2 -3 weeks after treatment

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20
Q

Acute Sid effects are related to

A

Total dose

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21
Q

Special acute effects

A

Tear glands, lung tissue, brain tissue

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22
Q

Topical treatment to acute side effects

A

Clean radiation site, ointments, vitamin E oil

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23
Q

Oral treatment for acute side effects

A

NSAID , Gabapentin, tramadol, opioids

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24
Q

Ointments used for acute side effects

A

Proteque and silvadene

25
Q

Late side effects of radiation are related to

A

Fraction size

26
Q

Late effects of radiation

A

Necrosis, fibrosis and secondary tumor

27
Q

Late side effects are known as

A

Stochastic events - random, months to years later

28
Q

Latest radiotherapy

A

Stereotactic radiotherpahhy

29
Q

SRS

A

Stereotactic radio surgery

30
Q

SRS was made for

A

Neuro tissue

31
Q

SRBT made for

A

Multiple fractions, tissue besides neuro

32
Q

Stereotactic radiotherapy can delivered what doses

33
Q

How many beans angle for SRS

34
Q

Each beam can have how many beamlets SRS

35
Q

Normal tissues receives what dose in SRS

36
Q

Tumor area receives what doses with SRS

37
Q

Gammaknife is what source

38
Q

Benefit of stereotactic radiotherapy

A

Less acute side effects, shorter course of radiation , less anesthesia

39
Q

Pitfalls fo SRS

A

Not all rumors can be treated, must have target, scar lines cannot be treated

40
Q

Late side effects of pituitary tumors

A

Blindness 8 - 12 months post treatment

41
Q

Best to treat pituitary treatment with

A

Congenital fractionated protocols

43
Q

Mast cell tumor have what chance of cure

44
Q

Brain tumors have what response rate

45
Q

Median survival time brain tumor

46
Q

Thyroid definitive median survival time

47
Q

Thyroid median survival time palliative

48
Q

Anal sac carcinomas definitive time

A

18 - 24 months

49
Q

Anal sac carcinomas palliative

A

12 - 18 months

50
Q

Nasal carcinoma.sarcoma response rate

51
Q

Definitive nasal carcinoma

A

12 - 18 months

52
Q

Palliative nasal carcinoma

A

6 - 8 months

53
Q

Nasal lymphoma definitive

A

18 - 24 months

54
Q

Nasal lymphoma palliative

A

2 - 12 months

55
Q

Oral malignant melanoma response rate 90

A

Oral squamous cell carcinoma definitive

56
Q

Oral squamous cell carcinoma Definitiev

57
Q

Palliative oral sq cell carcinoma dogs

58
Q

Oral sq cell carcinoma cats palliative

A

1/3 do not response

Oncology (11 decks)

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