13 - Feline Lymphoma

Question 1

Most common feline cancers

Answer 1

Feline lymphoma

Question 2

Most common anatomic locations for feline lymphoma

Answer 2

GI

Question 3

Risk factors for feline lymphoma

Answer 3

FELV, FIV,

Question 4

FELV direct role n

Answer 4

Tumorogenesis

Question 5

FIV indirect role in

Answer 5

Tumorogenesis

Question 6

Second hand tobacco smoke risk for feline lymphoma

Answer 6

2.8 x increase risk

Question 7

Inflammatory risk of feline lymphoma

Answer 7

IBD - LSA continuum

Question 8

Anatomic locations feline lymphoma classification

Answer 8

GI, mediastinal, nodal, extranodal

Question 9

How do you classify feline lymphoma

Answer 9

Anatomic location, histologic grade, immunophenotype

Question 10

Most prevalant location of GI feline lymphoma

Answer 10

Small intestine

Question 11

Mediastinal is most common location in

Answer 11

Young FeLV + cats

Question 12

Is nodal common form of lymph nodes

Answer 12

No

Question 13

A single nose is similar to

Answer 13

Hodgkin LSA

Question 14

Renal location of feline lymphoma in what cases

Answer 14

1/3 of extranodal

Question 15

50% of renal feline lymphoma will develop

Answer 15

CNS

Question 16

DDX renal feline lymphoma

Answer 16

polycystic kidney disease

Question 17

Second most common CNS malignancy in cats

Answer 17

CNS feline lymphoma

Question 18

Most common nasal tumor in cats

Answer 18

Lymphoma

Question 19

Most common form of extranodal LSA

Answer 19

Nasal

Question 20

How do you diagnose feline lymphoma

Answer 20

FNA cytology and biopsy - cytology is preferred

Question 21

GI LSA is usually small cell or large cell

Answer 21

Small

Question 22

Cytology is preferred in

Answer 22

Non lymphoid organs

Question 23

Non lymphoid organs

Answer 23

Effusions, kidneys, liver, focal GI mass

Question 24

Cons of cytology

Answer 24

Not for small cell GI LSA

Question 25

Gold standard for small cell GI

Answer 25

Biopsy - full thickness biopsy preferred

Question 26

Histopath can be difficult to differentiate

Answer 26

LSA from IBD

Question 27

Immunohistochemisty application of

Answer 27

Anti CD3 and CD20

Question 28

If a single phenotype is found with IH

Answer 28

LSA

Question 29

Signs of GI LSA in cats

Answer 29

Weight loss, vomiting, masses, thickened intestinal loops

Question 30

Signs of mediastinal LSA

Answer 30

Dyspnea, decreased thoracic compliance

Question 31

CBC of LSA

Answer 31

Anemia!

Question 32

What do we seem on chem with LSA

Answer 32

Hypoproteinemia - hypercalcemia (not common)

Question 33

Additional test may be indicated for patients such as

Answer 33

Bone marrow FNA , CT , MRI

Question 34

Do we use WHO staging scheme

Answer 34

Rarely

Question 35

Standard of care fo treatment for LSA in cats

Answer 35

Chemo

Question 36

Radiation in cats with which anatomic I

Answer 36

Nasal lymphoma, or one that is localized and not responsive

Question 37

For small cell what is treatment options

Answer 37

Oral chemotherapy- CHlorambucil / prednisolone

Question 38

What should you watch out for with prednisolone treatment

Answer 38

Diabetes

Question 39

3 main indication of radiation therapy

Answer 39

Localized, chemo resistant local lesion, CNS disease

Question 40

With treatment LAS in cat overall MST

Answer 40

Shorter than in dogs

Question 41

Without treatment MST for LSA

Answer 41

2 months

Question 42

Response to treatment LSA

Answer 42

1/3 rule

Question 43

Important prognostic indicators LSA feline

Answer 43

Response to treatment, anatomic locations feline lymphoma, histologic grade, FeLV status, chemotherapy protocol

Question 44

Alimentary LSA MST

Answer 44

1.5 years

Question 45

Mediastinal LSA MST

Answer 45

Feline + - 12 - 18 months

Question 46

Better prognosis in cats - 3

Answer 46

Small cell GI , Mediaastinal FeLV - , Nasal

Question 48

Not prognostic LSA

Answer 48

B cell v T cell, FIV status, Pre treatment with steroids