12 - Canine Lymphoma

Question 1

3 ways to classify lymphoma

Answer 1

Anatomic location, histologies grade and immunophenptype

Question 2

Most common location of lymphoma

Answer 2

Multicentric - nodal

Question 3

4 anatomic locations of lymphoma

Answer 3

Multicentric, alimentary, cranial med

Question 4

50% of Multicentric lymphoma have what involvement

Answer 4

Spleen and liver

Question 5

What is teh #1 differential for cranial mediastinal mass

Answer 5

Lymphoma and Thymoma

Question 6

2 options to classify lymphoma by grade

Answer 6

Large cell or small cell

Question 7

Is large cell or small cell more common

Answer 7

Large cell

Question 8

Which is lymphocytic high grade or low grade

Answer 8

Low grade

Question 9

2 ways to do lymphoma by phenotype

Answer 9

B cell and T cell

Question 10

immunophenotype

Answer 10

Cell subtype based on their surface markers

Question 11

Which cell surface marker is more common

Answer 11

B cell

Question 12

How to diagnose lymphoma

Answer 12

FNA cytology and biopsy

Question 13

Which cell type do we associate with hypercalcemia

Answer 13

T cell

Question 14

Most patients with lymphoma physical exam show

Answer 14

Peripheral lymphadenopathy and organomegaly

Question 15

CBC of lymphoma

Answer 15

Anemia, thrombocytopenia, neutrophilia, lymphocytosis

Question 16

40% dogs have

Answer 16

Hypercalcemia malignancy

Question 17

Serum of lymphoma

Answer 17

Increased liver enzymes and total bilirubin

Question 18

What percent of patients have cranial mediatstinal mass

Answer 18

20

Question 19

What percent have abnormalities with ultrasound

Answer 19

50

Question 20

When do you do bone marrow

Answer 20

If cytopenias on CBC

Question 21

Flow cytometryu will tell you if its

Answer 21

B cell or T cell

Question 22

Sample required for flow cytometry

Answer 22

Many live cells

Question 23

Clonality =

Answer 23

Malignancy

Question 25

Stage I

Answer 25

One lymph node

Question 26

Stage 2

Answer 26

Multiple nodes on the same side of diaphagrm

Question 27

Stage 3

Answer 27

Generalized lymphadenopathy

Question 28

Stage 4

Answer 28

Liver or spleen involved

Question 29

Stage 5

Answer 29

Bone marrow, peripheral blood, atypical location

Question 30

Two subtypes of WHO

Answer 30

A - healthy, b - sick

Question 31

What is the mainstay of treatment for lymphoma

Answer 31

Chemotherapy

Question 32

CR

Answer 32

Complete remission

Question 33

PR

Answer 33

Partial remission

Question 34

SD

Answer 34

Stable disease

Question 35

PD

Answer 35

Progressive disease

Question 36

Frontline protocol

Answer 36

Protocol of choice to induce remission

Question 37

Examples of frontline protocol

Answer 37

UW - Madison, Doxorubicin, COP

Question 38

COP

Answer 38

CHOP without doxorubicin

Question 39

Rescue

Answer 39

Protocol used at the time of relapse

Question 40

What chemotherapy crosses BBB

Answer 40

CCNU

Question 41

Tanovea

Answer 41

Small molecule drug not Classic chemotherapy

Question 42

MOA of tanovea

Answer 42

A cyclic nucleotide phosphate

Question 43

you cannot use tanovea

Answer 43

Westies

Question 44

Laserdisc

Answer 44

Small molecule drug

Question 45

MOA of laverdia

Answer 45

Selective inhibitor of nuclear transport and transport between nucleus and cytoplasm is important

Question 46

MOA of laverdia

Answer 46

Decreased appetite, anorexia, vomiting

Question 47

MST multi agent chemotherapy protocol

Answer 47

12 months

Question 48

MST without treatment

Answer 48

2 months

Question 49

What is response rate to single agent doxorubicin

Answer 49

85%

Question 50

MST wiht adriamycin contacting protocol is

Answer 50

1 year

Question 51

MST with prednisone alone

Answer 51

2 months