9) Maternal Medicine: Hypertension/PET Flashcards

1
Q

Incidence of hypertensive disorders in pregnancy (hypertension, PET, severe PET, eclampsia)

A

Hypertension: 8-10%
PET: 5%
Severe PET: 0.5%
Eclampsia : 1/4000

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2
Q

Major and minor risk factors for PET

A

MAJOR:

  • Hypertension
  • Previous PIH/PET
  • Chronic kidney disease
  • T1 or T2 DM
  • Autoimmune disorders

MINOR:

  • Age > 40
  • BMI > 35
  • First pregnancy
  • Inter-pregnancy interval > 10 years
  • Multiple pregnancy
  • FHx PET
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3
Q

When to admit?

A

Gestational hypertension: Only if severe (>16 0/110)

PET:

  • Sustained systolic BP >160
  • Severe PET (>160/110 or symptoms or fetal concerns)
  • Signs of impending eclampsia
  • Signs of impending pulmonary oedema
  • Abnormal bloods (Cr >90, ALT>70, Plts <150)
  • Fetal compromise
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4
Q

Target blood pressures

A

On treatment 135/85. Treat if persistently >140/90. (All types).

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5
Q

How often to monitor blood pressure?

A

Chronic hypertension: Weekly if poor control, 2-4 weekly if good control.

Gestational hypertension: 1-2 x per week if mild/moderate, if severe then every 15-30 minutes until <160/110 and then at least QDS whilst inpatient.

PET: Mild/moderate - at least every 48 hours. Severe - every 15-30 minutes until <160/110 and then QDS whilst inpatient.

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6
Q

How often to check urine?

A

Chronic hypertension: At each review

Gestational hypertension: Mild/moderate: 1-2 x per week. Severe then daily whilst admitted.

PET: Don’t repeat once established.

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7
Q

How often to do blood tests?

A

Chronic hypertension: Don’t need.
Gestational hypertension: Weekly (any severity).
PET: 2x per week if mild/moderate. 3 x per week if severe.

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8
Q

When to do growth scans?

A

Chronic hypertension: 28,32,36 weeks.
Gestational hypertension: Mild/moderate - every 2-4 weeks. Severe - every 2 weeks.
PET: Every 2 weeks.

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9
Q

What tests can be done if PET suspected in someone with chronic hypertension or gestational hypertension?

A

PIGF based testing 20-35 weeks. (Abnormally low in PET)

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10
Q

When to deliver?

A

Chronic/gestational hypertensives: After 37 weeks provided BP <160/110 unless another indication.

PET: Before 37 weeks if indication (including inability to control BP despite 3 or more classes of drugs in appropriate doses). After 37 weeks plan for delivery within 24-48 hours.

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11
Q

Postnatal BP measurements

A

Chronic hypertension: Daily D1/D2 and at least once D3-D5.
Review at 2/52 and 6-8/52.

Gestational hypertension:
Same.

PET:
QDS whilst inpatient.
If not medicated then once D3-D5 and alternate days after that if abnormal.
If medicated then every 1-2 days for 2 weeks until off treatment.

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12
Q

When to reduce blood pressure medication postnatal?

A

If BP <130/80 (consider if less than 140/90)

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13
Q

When can a PET patient be transferred to community?

A

No symptoms
BP <150/100
Bloods stable (measured 48-72h PN)

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14
Q

What to do if proteinuria still present at 6-8/52 check?

A

Repeat at 3/12 and if still present refer to renal

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15
Q

How often should BP be checked in labour?

A

Hourly (and every 15-30 minutes if >160/110)

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16
Q

WHen should MgSO4 be used for hypertension?

A
  • If eclampsia seizure
  • Severe PET and delivery planned for 24h
  • Consider if symptomatic/abnormal bloods
17
Q

Dosing of MgSO4

A

4 gram bolus over 5-15 minutes then 1g/h for 24h (or until 24h seizure free)
If recurrent fits then further bolus 2-4g

18
Q

Fluid balance precautions in PET

A

80ml/h in severe PET unless ongoing loss

Consider 500mL crystalloid only if using IV hydralazine.

19
Q

What do the three levels of care mean?

A

Level 3 - requiring ventilation
Level 2 - everything else! (AOCU)
Level 1 - conservative management (ward)

20
Q

Postnatal antihypertensives

A

(1) Enalapril
(2) Afro-Caribbean: Nifedipine or amlodipine

If single agent is ineffective:

  • Enalapril + nifedipine/amlodipine
  • Add labetalol/atenolol
21
Q

Overall risk of any type of hypertension in future having had any type of hypertension in pregnancy

A

20%

22
Q

I have had PET this pregnancy, what are my risks in the future?

A

PET but no early delivery: Risk of PET 16%
PET delivery 34-37w: Risk of PET 23%
PET delivery 28-34w: Risk of PET 33%
PET delivery <28w: Risk of PET 55%

Risk of gestational hypertension: 6-12%
Risk of chronic hypertension: 2%

23
Q

I have had PIH this pregnancy, what are my risks in the future?

A

PET: 7%
PIH: 14%
Chronic hypertension: 3%

24
Q

What cardiovascular risks in the future for someone with PET/PIH?

A

2 x increased risk of major cardiovascular adverse event, cardiovascular mortality, stroke and hypertension.

25
Q

Percentage of severe PET complicated by HELLP

A

20%

26
Q

Percentage of HELLP without proteinuria/hypertension

A

15%

27
Q

Percentage of HELLP with abruption

A

15%

28
Q

Timing of HELLP onset

A

15% 2nd trimester, 50% third trimester, remainder postnatal

29
Q

Blood tests to detect haemolysis

A

Abnormal peripheral blood film with fragmented red cells or increased reticulocyte count.
Raised unconjugated bilirubin.
Low haptoglobin.
Increased LDH.

30
Q

What percentage of cases of PET/PIH can be predicted by maternal history?

A

47% PET

35% PIH

31
Q

Most significant risk factor for PET

A

Maternal age

32
Q

Benefits of aspirin on PET

A

17% risk reduction in developing PET.
RR 0.6 PET and 0.3 severe PET.
NNT 19.

Reduced risks of PTL, foetal or neonatal death, FGR.

33
Q

Daily recommended calcium intake

A

1000mg/day

34
Q

Recommended calcium supplementation

A

1.5-2g per day from 20 weeks in populations where calcium intake is low.