9- Intro to Pharmacokinetics 2

Question 1

How to calculate the Maximum Concentration after a single IV bolus dose

Answer 1

Max = s x Dose (mg) / V (L)

Question 2

What does the s stand for in maximum concentration calcs

Answer 2

Salt correction factor if required

Question 3

How to calculate the concentration at any time after the dose

Answer 3

Ct = D/V x exp^-k x t

Question 4

How to calculate the elimination rate constant

Answer 4

Elim rate constant (k) = CL (L/h) / V(L)

Question 5

How to calculate the decline in concentration between two time points

Answer 5

Ct2 = Ct1 x e^k(t2-t1)

ie the hour u are on is equal to the first hour to the exponential of the difference

Question 6

How many sig figs should Elim half-life be presented in

Answer 6

3

Question 7

What is the easier formula used for elimination half life

Answer 7

0.693/K

Question 8

What are the two ways to plot the IV bolus concentration-time profile

Answer 8

Plot the natural log on regular graph paper

Plot the concentration on log graph paper