4- Intro to Pharmacokinetics

Question 1

Formula for Maximum Concentration

Answer 1

Maximum concentration (oral dose)

Cmax= F x Dose(mg) / V (L)

Question 2

Formula for IV loading dose

Answer 2

IV loading dose (Mg) = target Cpeak(mg/l) x V(L)

Question 3

Formula for Volume of distribution

Answer 3

V (L) = F x Dose (mg) / Cpeak (mg/L)

Question 4

Which organs are responsible for clearing drug out the body

Answer 4

ADULTS AND CHILDREN
Metabolism in the liver 97%
0.5% parent drug through kidneys

NEONATES
85% excretion of parent drug through the kidneys

Question 5

what clinical characteristics effect clearance of drugs

Answer 5

Weight
Liver function
Age
Enzyme activity (adults and children)
Drugs / foods / environmental factors that alter enzyme activity
Kidney function (neonates)

Question 6

Formula for calculating average steady-state concentration

Answer 6

Cav(mg/L)= F x Dose (mg) / Cl (L/h) x hours per dose