9. Bacterial and Misc Enteric Diseases Flashcards
Etiology of Clostridial Enterotoxemia
Clostridium spiroforme
Predisposition to clostridial enterotoxemia is caused by:
Decreased in fiber Weaning Change from restricted feeding to ad libitum feeding Stress Coinfections Abx
C/S of clostridial enterotoxemia
Peracute death
Wt loss
Anorexia
Most commonly: Watery diarrhea with fetid odor
Gross pathology of clostridial enterotoxemia
Hemorrhagic necrotic typhlitis
Paintbrush hemorrhages over serosa
Histopathology of Clostridial enterotoxemia
Large, fluid-filled, edmatous cecum
Mucosal cell swelling, vacuolation
What kind of diet fed to weanlings predisposes them to Clostridial enterotoxemia?
Low fiber, high energy diet
Causes cecal hypomotility and more availability of simple carbohydrates (required for C. spiroforme proliferation)
Rabbit vulnerability to C. spiroforme - adults vs weanlings
Exposure alone causes dz in weanlings
Exposure alone is not enough to cause dz in weanlings
Tx for Clostridial enterotoxemia
IV fluids
Transfaunation
Probiotics
Abx
Prevention of Clostridial enterotoxemia
Feeding practices - don’t overfeed, avoid early weaning, change feed gradually, provide sufficient fiber
Colibacillosis etiology
E. coli
E. coli is normally found in the GI of rabbits - T or F?
F
What changes in cecal pH may cause colibacillosis?
Increases in cecal pH
5 types of pathogenic E. coli?
- Enteroinvasive
- Enterotoxic
- Enterohemorrhagic
- Enteroaggregative
- Enteropathogenic
Most common E. coli strain involved in rabbit enteric disease
Enteropathogenic
How does enteropathogenic E. coli cause disease?
Attach to mucosal surface, effacing the epithelium (flattening it)
This causes loss of microvilli, leading to diarrhea
Colibacillosis is seen most commonly in which age group/
4-6 week old weanlings
E. coli on histo
Colonies adhered to colon surface
Tx for colibacillosis
Supportive care (fluids)
Abx (quinolone)
High fiber diet
Cull severely affected animals
Tyzzer’s triad
Heart, intestines, liver
Primary site of infection of Tyzzer’s
GI ,then goes to heart and liver
C. piliforme gram positive or negative?
Obligate intracellular gram positive organism (but can appear gram negative)
Tramission of Tyzzer’s
Ingestion of spores
C/S of Tyzzer’s
Most infections are subclinical
Diarrhea, listlessness, anorexia, dehydration, death
Gross pathology of Tyzzers
Ecchymotic or petechial hemorrhages on serosal surface
Histo of Tyzzers
Silver stain shows “pickup sticks”
Multifocal tan to yellow foci of necrosis or heomrrhage in myocardium
Tx of Tyzzers
Abx are ineffective due to brief clinical course, intracellular location, spore formation
Culling
How should Tyzzers spores be decontaminated
1% peracetic acid or chlorine dioxide
Salmonella spp implicated in salmonellosis in rabbits
Salmonella enterica
Pathogenesis of Salmonella
Fecal oral transmission, organisms colonize ileum and LI
They invade epithelium, transported to lymphoid cells
Once intracellular, they proliferate in phagosomes
C/S of salmonellosis
Usually peracute, lethal with few clinical signs
Septicemia, diarrhea
Tx of Salmonellosis
Cull
Lawsonia has a strong tropism for which cells?
Crypt cells
C/S of Lawsonia
Diarrhea, wt loss, dehydration, depression
Stain for Lawsonia
Warthin-Starry
Tx for Lawsonia
Fluids
Etiology of mucoid enteropathy
Unknown , but associated with E. coli, Clostridium, Eimeria
Theory of mucoid enteropathy pathogenesis
Cecum pH decrease causes GI flora change
Mucoid enteropathy gross pathology
Lumen of Si and LI plugged with mucus, esp ileum
Tx for ME
Supportive care
Withhold food
ad lib water
High qual alfalfa hay and salt for 1 week
Gradually return to normal feed over a week
ME prevention
High quality feed with 12-14% fiber content
High fiber increases motility and reduces carbs available for hindgut fermentation
Where will trichobezoar form most commonly?
Pylorus
Tx for trichobezoar
Hydration, nutritional support, metoclopramide