8. Viral Diseases of Rabbits

Question 1

Adenovirus c/s

Answer 1

Enteritis in 6-8 week olds

Profuse diarrhea with low mortality

Question 2

Rabbit parvovirus c/s

Answer 2

Asymptomatic

Question 3

Etiology of Shope Papillomavirus

Answer 3

Cottontail Rabbit Papillomavirus

Question 4

CRPV is in what family?

Answer 4

Papovaviridae

Question 5

Transmission of CRPV

Answer 5

Insects, particularly rabbit ticks (Haemaphysalis leporis) and mosquitoes

Question 6

Natural host of CRPV

Answer 6

Sylvilagus spp

Question 7

CRPV c/s

Answer 7

Large, keratinized warts over neck, shoulder, abdomen

Question 8

Why shouldn’t you worry about transmission of CRPV in a lab animal colony?

Answer 8

Oryctolagus do not shed as many virions as natural Sylvilagus host

Question 9

Do CRPVs papillomas occur in the mouth in rabbits?

Answer 9

no

Question 10

CRPVs Papillomas that do not regress turn into what?

Answer 10

SCC

Question 11

25% of rabbits with SCC die due to what?

Answer 11

Metastasis

Question 12

Which papillomavirus has Oryctolagus as natural host?

Answer 12

Rabbit Oral Papillomavirus

Question 13

Where do rabbit oral papillomas occur?

Answer 13

Ventral tongue of 2-18 month old rabbits

Question 14

Disease timeline of oral papillomas

Answer 14

Usually regress within a few weeks

Question 15

Myxomavirus is what kind of virus?

Answer 15

Leporipoxvirus

Question 16

Where is myxomatosis endemic?

Answer 16

Southwestern US

Question 17

Natural reservoir of myxomatosis

Answer 17

Brush rabbit (Sylvilagus)

Question 18

Myxoma virus transmission

Answer 18

Arthropod vector

Question 19

Myxomavirus c/s in Oryctolagus

Answer 19

Severe disease with high mortality

Question 20

2 different strains of Myxomavirus

Answer 20

California strain - death within 1 week

South American strain - mean survival time of 11 days

Question 21

C/S of myxomavirus

Answer 21

Edema, mucopurulent discharge. South American strain causes hard, convex lumps over the body, head, ears

Question 22

Efficacy of Myxomavirus vaccine

Answer 22

Reduces mortality and c/s, not entirely protective

Question 23

Shope Fibroma Virus causes high mortality in which rabbits?

Answer 23

Neonates

Question 24

Why aren’t Oryctolagus a good source of infection for mosquitoes?

Answer 24

Low virus concentration in the skin

Question 25

C/S of shope fibroma virus

Answer 25

Firm, flattened tumors on legs, feet periorbital, perineal regions. Spontaneous regression occurs

Question 26

Shope fibrama vs Shope papilloma

Answer 26

Fibroma - flat, SQ, loose, rubbery. | Papilloma - heavily keratinized, irregular, projecting masses of skin

Question 27

Rabbit poxvirus C.S

Answer 27

Profuse nasal discharge -> macular papules over skin, spleen, resp tract, liver Death in 7-10 days.

Question 28

Which poxvirus doesn't have inclusion bodies?

Answer 28

Rabbit pox virus

Question 29

Leporid Herpesvirus 1 secondary name

Answer 29

Herpes sylvilagus

Question 30

Herpes sylvilagus C/S

Answer 30

No infection or dz in domesticated rabbits

Question 31

Herpes sylvilagus is a member of what family?

Answer 31

Gammaherpesvirus

Question 32

Leporid Herpesvirus 2 is a member of what family?

Answer 32

Gammaherpesvirus

Question 33

Leporid Herpesvirus 4 is a member of what family?

Answer 33

Alphaherpesvirus

Question 34

LHP-2 c/s

Answer 34

Asymptomatic

Question 35

LHP-4 c/s

Answer 35

High morbidity and mortality | Periocular swelling, purulent ocular d/c, hemorrhagic dermatitis, ataxia, torticollis, CNS signs

Question 36

Rabbits are a model for what herpesvirus?

Answer 36

HHV-1

Question 37

HHV-1 C/S in rabbits

Answer 37

CNS signs

Question 38

4 distinct species of Rabbit Calicivirus

Answer 38

Rabbit hemorrhagic disease virus European brown hare syndrome virus Rabbit calicivirus Michigan rabbit calicivirus

Question 39

Calicivirus c/s

Answer 39

Very high morbidity, 100% mortality

Question 40

Major cause of death from calicivirus

Answer 40

DIC with deep vein thrombosis

Question 41

What may be the only lesion found with calicivirus?

Answer 41

Pale liver with periportal necrosis

Question 42

Calicivirus should be reported to whom?

Answer 42

State vet and USDA

Question 43

Rabbit Enteric Coronavirus clinical course

Answer 43

Death within 24 hours of c/s | Cardiomyopathy and pleural effusion also possible

Question 44

Rotavirus is within which family?

Answer 44

Reovirus

Question 45

When does rotavirus usually occur?

Answer 45

When maternal Abs wear off during weaning

Question 46

C/S of rotavirus

Answer 46

In neonates: Severe dz and death >2weeks: few to no c/s Diarrhea